{"doi":"10.1016/j.jbiosc.2025.02.007","title":"Application of silica monoliths for improved storage stability of metabolites in human plasma","abstract":null,"journal":"Journal of Bioscience and Bioengineering","year":2025,"id":601126,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":814524,"name":"Eiichiro Fukusaki","orcid":"0000-0003-3069-5547","position":1,"is_corresponding":false},{"id":899605,"name":"Kazuhiro Kawamura","orcid":"0000-0001-5572-9171","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Application of silica monoliths for improved storage stability of metabolites in human plasma","abstract":"In metabolomic studies, sample collection and analysis are typically performed at separate locations, necessitating the transport and storage of samples. However, sample transport and storage conditions are often constrained by the available facilities. Specifically, metabolite levels in biological and food samples can fluctuate due to the activity of endogenous enzymes, depending on the transport and storage conditions. Therefore, in this study, we aimed to achieve metabolite stabilization during storage by sampling human plasma on silica monoliths. Silica monoliths maintained the metabolite samples in a dry state, enabling their transport and storage at high temperatures. Plasmas stored at room temperature and refrigerated were measured using gas chromatography/mass spectrometry (GC/MS), and the fluctuations in metabolites between normal storage and storage on silica monoliths were compared. As a result, fluctuations in several metabolites such as glucose and amino acids were observed during normal storage. However, these were suppressed during storage on silica monoliths. Overall, our findings highlight the efficiency of silica monoliths for sample transport and storage at high temperatures.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40087073","pmcid":null,"openalex_id":"https://openalex.org/W4408421561","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.02782134,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1389172325000490?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1389172325000490?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jbiosc.2025.02.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40087073","host_type":"repository"}],"fields_of_study":["Metabolomics and Mass Spectrometry Studies","Analytical Chemistry and Chromatography","Alcohol Consumption and Health Effects","Humans","Silicon Dioxide","Gas Chromatography-Mass Spectrometry","Metabolomics","Plasma","Specimen Handling","Amino Acids","Temperature"],"mesh_terms":["Amino Acids","Humans","Gas Chromatography-Mass Spectrometry","Plasma","Silicon Dioxide","Specimen Handling","Temperature","Metabolomics"],"keywords":["Human plasma","Chromatography","Chemistry","Plasma","Physics","Metabolomics","Silica Monolith","Metabolite Stability","Monotrap","Gas–solid Phase Derivatization"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T15:12:57.613425Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}