{"doi":"10.1016/j.jbc.2026.113174","title":"Higher-order structural organization of mitochondrial metabolism","abstract":null,"journal":"Journal of Biological Chemistry","year":2026,"id":654896,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1709288,"name":"Jonas Döbler","orcid":"0009-0008-4308-3447","position":1,"is_corresponding":false},{"id":314549,"name":"Panagiotis L. 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We report on recent data on mitochondrial enzyme filamentation, higher-order metabolons, enzyme-gating mechanisms, and contact-site nanostructures. In addition to single-particle cryo-EM results, we discuss emerging in situ cryo-tomography data, the integration of traditional structural biology approaches, and the use of in silico models for less-studied pathways. By mapping hundreds of recent mitochondrial structures, we provide a roadmap that connects structural biochemistry with cell physiology, disclosing the molecular basis of mitochondrial disease. Our collected resources may guide future integrative research aiming to elucidate mitochondrial architecture and function across organisms and conditions.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42167575","pmcid":null,"openalex_id":"https://openalex.org/W7161813077","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"101086665","title":null},{"funder_name":"European Regional Development Fund","grant_id":"ZS/2016/04/78115","title":null},{"funder_name":"European Regional Development Fund","grant_id":"ZS/2024/05/187255","title":null},{"funder_name":"Bundesministerium für Forschung, Technologie und Raumfahrt","grant_id":"03Z22HN23,03Z22HI2","title":null},{"funder_name":"Bundesministerium für Forschung, Technologie und Raumfahrt","grant_id":"/2016/04/78115andZS/2024/05/187255","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"514901783","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"RTG 2467","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"391498659","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"SFB 1664 [A04, C04, and D01]","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"SFB 1664","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"C04","title":null},{"funder_name":"Utbildningsdepartementet","grant_id":"","title":null},{"funder_name":"Martin-Luther-Universität Halle-Wittenberg","grant_id":"","title":null}],"total_grants":13,"fwci":0.0,"citation_percentile":0.47922231,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jbc.2026.113174","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jbc.2026.113174","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925826020466?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925826020466?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42167575","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13311838/","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","Origins and Evolution of Life","Cancer and biochemical research","Mitochondria","Humans","Cryoelectron Microscopy","Animals"],"mesh_terms":["Animals","Humans","Mitochondria","Cryoelectron Microscopy"],"keywords":["Mitochondrion","Metabolism","Mitochondrial DNA","Cell metabolism","Energy metabolism","Supramolecular Assemblies","Scaffolding","Conformational Landscape","Lipid–protein Interactions","Integrative Structural Modeling","Metabolic Modularity","Dynamic Protein Complexes","Mitochondrial Metabolons","Structural And Molecular Biology","Filamentous Enzyme Regulation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T08:48:52.772951Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}