{"doi":"10.1016/j.jbc.2025.110891","title":"Conserved +1 translational frameshifting in the Saccharomyces cerevisiae gene encoding YPL034W","abstract":"Cells have developed exquisite mechanisms to ensure accurate translation of mRNA, including preventing a change in reading frame during translation elongation. A minority of chromosomally encoded genes have evolved sequences that subvert standard decoding to program +1 translational frameshifting, either constitutively or in response to external stimuli. In the yeast Saccharomyces cerevisiae, three chromosomal genes are known to employ programmed +1 translational frameshifting for expression of full-length functional products. Here, we identify a fourth yeast gene, YFS1, encompassing the existing predicted open reading frame YPL034W, with conserved programmed +1 frameshifting. Like the previously known examples, YFS1 appears to exploit peculiarities in tRNA abundance in S. cerevisiae to promote frameshifting.","journal":"Journal of Biological Chemistry","year":2025,"id":535283,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9471,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":497764,"name":"Swati Gaikwad","orcid":"0000-0002-1438-9497","position":1,"is_corresponding":false},{"id":1418870,"name":"Byung Sik Shin","orcid":"0009-0005-3454-6516","position":2,"is_corresponding":false},{"id":326039,"name":"Alan G. Hinnebusch","orcid":"0000-0002-1627-8395","position":3,"is_corresponding":false},{"id":282078,"name":"Thomas Dever","orcid":"0000-0001-7120-9678","position":4,"is_corresponding":false},{"id":48149,"name":"Ivaylo P. Ivanov","orcid":"0000-0002-6008-3261","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41197732","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}