{"doi":"10.1016/j.jbc.2025.108267","title":"AnimalGWASAtlas: Annotation and prioritization of GWAS loci and quantitative trait loci for animal complex traits","abstract":null,"journal":"Journal of Biological Chemistry","year":2025,"id":600016,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":24030,"name":"Yunhan Jing","orcid":null,"position":1,"is_corresponding":false},{"id":1393852,"name":"Yifei Wang","orcid":"0000-0003-0562-3058","position":2,"is_corresponding":false},{"id":920841,"name":"Xingyu Li","orcid":"0000-0002-2456-8042","position":3,"is_corresponding":false},{"id":406369,"name":"Jing Yang","orcid":"0000-0002-6784-9012","position":4,"is_corresponding":false},{"id":1071445,"name":"Kai Wang","orcid":"0000-0003-4328-8799","position":5,"is_corresponding":false},{"id":24032,"name":"Hengdong He","orcid":null,"position":6,"is_corresponding":false},{"id":592246,"name":"Yuan Yang","orcid":"0000-0002-2914-9832","position":7,"is_corresponding":false},{"id":24037,"name":"Yuanling Tang","orcid":null,"position":8,"is_corresponding":false},{"id":804100,"name":"Chen Wang","orcid":"0009-0005-6441-5939","position":9,"is_corresponding":false},{"id":770479,"name":"Jun Xu","orcid":"0000-0003-4617-6602","position":10,"is_corresponding":false},{"id":1294743,"name":"Fan Yang","orcid":"0000-0003-3671-4745","position":11,"is_corresponding":false},{"id":24044,"name":"Mingzhou Li","orcid":"0000-0001-8681-7684","position":12,"is_corresponding":false},{"id":24045,"name":"Qianzi Tang","orcid":"0000-0003-3235-3372","position":13,"is_corresponding":false},{"id":24029,"name":"Yuwei Gou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"AnimalGWASAtlas: Annotation and prioritization of GWAS loci and quantitative trait loci for animal complex traits","abstract":"Genome-wide association study (GWAS) and quantitative trait locus (QTL) mapping methods provide valuable insights and opportunities for identifying functional gene underlying phenotype formation. However, the majority of GWAS risk loci and QTLs located in noncoding regions poses significant challenges in pinpointing the protein-coding genes associated with specific traits. Moreover, growing evidence suggests not all GWAS risk loci and QTLs are functional, emphasizing the critical need for prioritizing causal sites-a task of paramount importance for biologists. The accumulation of publicly available multiomics data provides an unprecedented opportunity to annotate and prioritize GWAS risk loci and QTLs. Therefore, we developed a comprehensive multiomics database encompassing four major agricultural species-pig, sheep, cattle, and chicken. This database integrates publicly accessible datasets, including 140 GWAS studies (covering 471 traits), 2625 QTL datasets (spanning 1235 traits), 86 Hi-C datasets (from eight cells/tissue types), 95 epigenomic datasets (from four cells/tissue types), and 769 transcription factor motifs. The database aims to link GWAS-QTL loci located in the noncoding regions to the target genes they regulate and prioritize functional and causal regulatory elements. Ultimately, it provides a valuable resource and potential validation targets for elucidating the genes and molecular pathways underlying economically important traits in agricultural animals.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39909383","pmcid":"PMC11904539","openalex_id":"https://openalex.org/W4407095963","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"32225046","title":null},{"funder_name":"Sichuan Provincial Science and Technology Support Program","grant_id":"2021YFYZ0009","title":null},{"funder_name":"Sichuan Provincial Science and Technology Support Program","grant_id":"2021ZDZX0008","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2020YFA0509500","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFF1000100","title":null},{"funder_name":"Sichuan Province Science and Technology Support Program","grant_id":"","title":null}],"total_grants":6,"fwci":4.8772,"citation_percentile":0.94504241,"influential_citations":0,"citation_trend":[{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.jbc.org/article/S0021-9258(25)00114-0/pdf","host_type":"journal"},{"url":"https://www.jbc.org/article/S0021-9258(25)00114-0/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925825001140?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925825001140?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jbc.2025.108267","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39909383","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11904539","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11904539/pdf/main.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11904539","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11904539?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Genetic and phenotypic traits in livestock","Genetic Mapping and Diversity in Plants and Animals","Cancer-related molecular mechanisms research"],"mesh_terms":["Animals","Cattle","Chickens","Sheep","Swine","Databases, Genetic","Quantitative Trait Loci","Genome-Wide Association Study","Molecular Sequence Annotation"],"keywords":["Quantitative trait locus","Genome-wide association study","Expression quantitative trait loci","Biology","Family-based QTL mapping","Computational biology","Genetics","Genetic association","Trait","Epigenomics","Gene","Locus (genetics)","Genetic architecture","Gene mapping","Single-nucleotide polymorphism","Computer science","Genotype","DNA methylation","Gene expression","Databases","QTL","Bioinformatics","Genomics","Gwas"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"ensembl"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T11:59:43.990396Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}