{"doi":"10.1016/j.jbc.2024.107499","title":"ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia","abstract":"Blood amino acid levels are maintained in a narrow physiological range. The pancreatic α cells have emerged as the primary aminoacidemia regulator through glucagon secretion to promote hepatic amino acid catabolism. Interruption of glucagon signaling disrupts the liver-α cells axis leading to hyperaminoacidemia, which triggers a compensatory rise in glucagon secretion and α cell hyperplasia. The mechanisms of hyperaminoacidemia-induced α cell hyperplasia remain incompletely understood. Using a mouse α cell line and in vivo studies in zebrafish and mice, we found that hyperaminoacidemia-induced α cell hyperplasia requires ErbB3 signaling. In addition to mechanistic target of rapamycin complex 1, another ErbB3 downstream effector signal transducer and activator of transcription 3 also plays a role in α cell hyperplasia. Mechanistically, ErbB3 may partner with ErbB2 to stimulate cyclin D2 and suppress p27 via mechanistic target of rapamycin complex 1 and signal transducer and activator of transcription 3. Our study identifies ErbB3 as a new regulator for hyperaminoacidemia-induced α cell proliferation and a critical component of the liver-α cells axis that regulates aminoacidemia.","journal":"Journal of Biological Chemistry","year":2024,"id":444959,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1260364,"name":"Jianxin Jia","orcid":"0000-0001-8578-5115","position":1,"is_corresponding":false},{"id":343974,"name":"E. Danielle Dean","orcid":"0000-0002-7157-5683","position":2,"is_corresponding":false},{"id":1260365,"name":"Hang Yuan","orcid":"0009-0001-3135-582X","position":3,"is_corresponding":false},{"id":250522,"name":"Chunhua Dai","orcid":"0000-0002-6302-7126","position":4,"is_corresponding":false},{"id":1260366,"name":"Zhehui Li","orcid":"0009-0003-0347-309X","position":5,"is_corresponding":false},{"id":1260367,"name":"Fuquan Jiang","orcid":"0000-0002-8628-5339","position":6,"is_corresponding":false},{"id":131467,"name":"Xiao-kun Zhang","orcid":null,"position":7,"is_corresponding":false},{"id":7379,"name":"Alvin C. Powers","orcid":"0000-0003-1941-5786","position":8,"is_corresponding":false},{"id":325641,"name":"Wenbiao Chen","orcid":"0000-0002-0750-8275","position":9,"is_corresponding":false},{"id":264061,"name":"Mingyu Li","orcid":"0000-0003-1217-2929","position":10,"is_corresponding":false},{"id":706302,"name":"Qi Kang","orcid":"0000-0003-0592-1557","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T02:01:37.886033Z","pmid":"38944125","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}