{"doi":"10.1016/j.jbc.2023.105028","title":"Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection","abstract":"As part of the antiviral response, cells activate the expressions of type I interferons (IFNs) and proinflammatory mediators to control viral spreading. Viral infections can impact DNA integrity; however, how DNA damage repair coordinates antiviral response remains elusive. Here we report Nei-like DNA glycosylase 2 (NEIL2), a transcription-coupled DNA repair protein, actively recognizes the oxidative DNA substrates induced by respiratory syncytial virus (RSV) infection to set the threshold of IFN-β expression. Our results show that NEIL2 antagonizes nuclear factor κB (NF-κB) acting on the IFN-β promoter early after infection, thus limiting gene expression amplified by type I IFNs. Mice lacking Neil2 are far more susceptible to RSV-induced illness with an exuberant expression of proinflammatory genes and tissue damage, and the administration of NEIL2 protein into the airway corrected these defects. These results suggest a safeguarding function of NEIL2 in controlling IFN-β levels against RSV infection. Due to the short- and long-term side effects of type I IFNs applied in antiviral therapy, NEIL2 may provide an alternative not only for ensuring genome fidelity but also for controlling immune responses.","journal":"Journal of Biological Chemistry","year":2023,"id":357903,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1107687,"name":"Yaoyao Xue","orcid":"0000-0003-2137-6181","position":1,"is_corresponding":false},{"id":278896,"name":"Ke Wang","orcid":"0000-0002-5305-6791","position":2,"is_corresponding":false},{"id":1107688,"name":"Xu Zheng","orcid":"0000-0001-5523-7177","position":3,"is_corresponding":false},{"id":687792,"name":"Azharul Islam","orcid":"0000-0003-4958-5057","position":4,"is_corresponding":false},{"id":687791,"name":"Nisha Tapryal","orcid":"0000-0002-7598-4273","position":5,"is_corresponding":false},{"id":348399,"name":"Anirban Chakraborty","orcid":"0000-0002-6558-0179","position":6,"is_corresponding":false},{"id":126396,"name":"Attila Bácsi","orcid":"0000-0002-2311-2975","position":7,"is_corresponding":false},{"id":826388,"name":"Xueqing Ba","orcid":"0000-0002-1075-5496","position":8,"is_corresponding":false},{"id":348403,"name":"Tapas K. Hazra","orcid":"0000-0002-4587-687X","position":9,"is_corresponding":false},{"id":724067,"name":"István Boldogh","orcid":"0000-0002-0088-1130","position":10,"is_corresponding":false},{"id":826385,"name":"Lang Pan","orcid":"0000-0003-2324-2144","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:13:39.186262Z","pmid":"37423306","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}