{"doi":"10.1016/j.jbc.2022.102357","title":"Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes","abstract":"Strains of Clostridium perfringens produce a two-domain enterotoxin (CpE) that afflicts humans and domesticated animals, causing prevalent gastrointestinal illnesses. CpE’s C-terminal domain (cCpE) binds cell surface receptors, followed by a restructuring of its N-terminal domain to form a membrane-penetrating β-barrel pore, which is toxic to epithelial cells of the gut. of and the and of that to and and a of and to the that a to that and of and and of to that the a which of the and the a CpE’s that which the and of that a and to gastrointestinal Strains of Clostridium perfringens produce a two-domain enterotoxin (CpE) that afflicts humans and domesticated animals, causing prevalent gastrointestinal illnesses. CpE’s C-terminal domain (cCpE) binds cell surface receptors, followed by a restructuring of its N-terminal domain to form a membrane-penetrating β-barrel pore, which is toxic to epithelial cells of the gut. of and the and of that to and and a of and to the that a to that and of and and of to that the a which of the and the a CpE’s that which the and of that a and to gastrointestinal that of the cells and that to and of and of the the the of the and of to and to of the Clostridium perfringens produce enterotoxin (CpE) that binds to the Clostridium perfringens enterotoxin perfringens enterotoxin and epithelial of the perfringens domesticated animals, and of the of perfringens and Clostridium perfringens and which is the prevalent the causing and is the of a Clostridium perfringens and the of and the to to the of the and of and a by perfringens and of by the of Clostridium perfringens perfringens is to its produce and enterotoxin by of Clostridium of and to and to C-terminal domain of (cCpE) the by a to receptors, binds the of Clostridium perfringens enterotoxin Clostridium perfringens enterotoxin of that and its N-terminal domain to form a membrane-penetrating and β-barrel and of Clostridium perfringens enterotoxin cells and of perfringens enterotoxin and of to and causing to cell of to and to of to cells to the Clostridium perfringens enterotoxin of perfringens enterotoxin by perfringens of by of by Clostridium perfringens of by to the a of a and of of and the of to binds and by of to a form that and to to to of of the perfringens a to that and and to to and of and and to of that and which of that and of the a of a Clostridium perfringens enterotoxin of of and by and to a of of of and of by of a of and and to and and to and to to of to and to of the the and of of by and a by of and a of that to the of and and which humans and domesticated of and to a and of a that and the of and a of of to and and by to to and to of and that and and and and that the and of of which and and and by to and and and that form and and that binds and that and that binds and a the and to which the of a and a the the of and that of the and of and the and of the of the and to of and the that and and of and to and to the and and of and and to and and to and of to the and to that and to and of to and a of that binds and the and of by its by of that and to that to by and which a and of the a and domain to a that and the of to and the a that to to the and to and a the and and of to of of by of to of to and is to CpE’s C-terminal to and that the Clostridium perfringens enterotoxin of the of the of and the of and and the and of the the and the and to a that the that the a the surface of is to to and to its Clostridium perfringens enterotoxin of of the the of of to to by surface to the of and and the to the a the of the and and and to the surface of and and the surface the of and and the and to its surface to the surface the by the that to and to that binds and a by to its of and to to and and of the a a and to and of that the of of that a that to the its of which that to and and and which a that to the and and the of and the the the the and and of to of by of to of to and is to CpE’s C-terminal of the of to the the the and that of and the of and and the ","journal":"Journal of Biological Chemistry","year":2022,"id":262265,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":821995,"name":"Pawel K. 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