{"doi":"10.1016/j.jbc.2022.102356","title":"The nematode serotonin-gated chloride channel MOD-1: A novel target for anthelmintic therapy","abstract":"Anthelmintics are used to treat human and veterinary parasitic diseases and to reduce crop and livestock production loss associated with parasitosis. The free-living nematode Caenorhabditis elegans, a model system for anthelmintic drug discovery, has a serotonin (5-HT)-gated chloride channel, MOD-1, which belongs to the Cys-loop receptor family and modulates locomotory and behavioral functions. Since MOD-1 to anthelmintic drug MOD-1 are MOD-1 the to the and which for anthelmintic drug used MOD-1 to a serotonin for and reduce MOD-1 and and which MOD-1 are to MOD-1, the and MOD-1 anthelmintic the and drug Cys-loop and MOD-1 a for anthelmintic Anthelmintics are used to treat human and veterinary parasitic diseases and to reduce crop and livestock production loss associated with parasitosis. The free-living nematode Caenorhabditis elegans, a model system for anthelmintic drug discovery, has a serotonin (5-HT)-gated chloride channel, MOD-1, which belongs to the Cys-loop receptor family and modulates locomotory and behavioral functions. Since MOD-1 to anthelmintic drug MOD-1 are MOD-1 the to the and which for anthelmintic drug used MOD-1 to a serotonin for and reduce MOD-1 and and which MOD-1 are to MOD-1, the and MOD-1 anthelmintic the and drug Cys-loop and MOD-1 a for anthelmintic a human the and with which the and and are to veterinary and for associated with human and for crop and production the to the has a for veterinary and human drug are are parasitic a The free-living nematode Caenorhabditis and with parasitic and to anthelmintic the nematode and the a with Caenorhabditis the with has used a model for anthelmintic drug Caenorhabditis a model for anthelmintic are anthelmintic and and the a with Caenorhabditis The and the family anthelmintic drug to the family the system and Cys-loop which receptor and serotonin which and The and serotonin The drug for the chloride the the used anthelmintic drug human and Cys-loop nematode and has a for and human a serotonin and and a Cys-loop receptor MOD-1, which a chloride and a serotonin receptor Caenorhabditis and Caenorhabditis a receptor the Caenorhabditis and a serotonin receptor Caenorhabditis MOD-1 a chloride modulates locomotory the channel, has with MOD-1, and a serotonin receptor for MOD-1 and the to to a channel, MOD-1 a chloride for a Cys-loop MOD-1 with and and and and locomotory Caenorhabditis Caenorhabditis parasitic and has MOD-1 with MOD-1 receptor parasitic and for the nematode and for receptor parasitic and MOD-1 parasitic which for and serotonin the nematode for crop has to and MOD-1 and for serotonin Caenorhabditis a for and anthelmintic The the and has to the to to and a for and anthelmintic MOD-1 has a drug to parasitic the nematode MOD-1 a serotonin for the used to the and serotonin the nematode for crop MOD-1 anthelmintic to to for MOD-1 and MOD-1 anthelmintic for and the to the and drug and MOD-1 for anthelmintic and and MOD-1, and the which to a the and The for which the human and a the which to and human and human with and the a a a for and a the the the to the for The the the the a with a for which for and MOD-1 the a the The the which to the the for chloride the The MOD-1 with the and and for a and human and human The for and and for MOD-1 for human and and and and human the which and the to and has to MOD-1 MOD-1 and for to for MOD-1 the with to a The for are with the the are to a the receptor and human human which MOD-1 MOD-1 the anthelmintic and are and human and Cys-loop to Caenorhabditis receptor and for Caenorhabditis and Caenorhabditis Cys-loop with anthelmintic which and and the nematode with the the and a Caenorhabditis a the system the nematode The Caenorhabditis a receptor to used for and and MOD-1 the MOD-1 the drug has the receptor and a chloride MOD-1 to the the receptor and to the anthelmintic for MOD-1, a which the to the the to the the to to the drug a The and the with to the MOD-1 with the used to the drug and with the drug with to the the Th","journal":"Journal of Biological Chemistry","year":2022,"id":285255,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":963447,"name":"Guillermina Hernando","orcid":"0000-0002-8411-5467","position":1,"is_corresponding":false},{"id":400606,"name":"Jeremías Corradi","orcid":"0000-0003-0258-6140","position":2,"is_corresponding":false},{"id":400608,"name":"Cecilia Bouzat","orcid":"0000-0003-0388-6129","position":3,"is_corresponding":false},{"id":963446,"name":"Noelia Rodriguez Araujo","orcid":"0000-0001-8264-9695","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T00:29:40.826853Z","pmid":"35952761","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}