{"doi":"10.1016/j.jbc.2022.102306","title":"The 5′-phosphate enhances the DNA-binding and exonuclease activities of human mitochondrial genome maintenance exonuclease 1 (MGME1)","abstract":"In higher eukaryotes, mitochondria play multiple roles in energy production, signaling, and biosynthesis. Mitochondria possess multiple copies of mitochondrial DNA (mtDNA), which encodes 37 genes that are essential for mitochondrial and cellular function. When mtDNA is challenged by endogenous and exogenous factors, mtDNA undergoes repair, degradation, and compensatory synthesis. mtDNA degradation is an emerging pathway in mtDNA damage response and maintenance. A key factor involved is mitochondrial and of DNA DNA of is of for of mtDNA of and and of that and of DNA in of which an in DNA and by In in that and and of and for of of DNA in mtDNA In higher eukaryotes, mitochondria play multiple roles in energy production, signaling, and biosynthesis. Mitochondria possess multiple copies of mitochondrial DNA (mtDNA), which encodes 37 genes that are essential for mitochondrial and cellular function. When mtDNA is challenged by endogenous and exogenous factors, mtDNA undergoes repair, degradation, and compensatory synthesis. mtDNA degradation is an emerging pathway in mtDNA damage response and maintenance. A key factor involved is mitochondrial and of DNA DNA of is of for of mtDNA of and and of that and of DNA in of which an in DNA and by In in that and and of and for of of DNA in mtDNA DNA is DNA of which encodes of and mtDNA in of of and of mitochondrial DNA and emerging and of mitochondrial of mitochondrial DNA and in mitochondrial in mitochondrial DNA of mtDNA are involved in mtDNA in genes mtDNA and in DNA for of mitochondrial DNA and mitochondrial DNA in in DNA in mitochondrial DNA mitochondrial in mtDNA and mitochondrial and mitochondrial in DNA in mtDNA and mtDNA in mtDNA and of mtDNA and in of mitochondrial for of DNA of involved in DNA and and of mitochondrial mitochondrial mtDNA mitochondrial DNA by and is of mitochondrial mitochondrial in DNA in mtDNA and mitochondrial of mitochondrial for of DNA mitochondrial mtDNA mtDNA and mtDNA of an in DNA in mtDNA and mitochondrial of mitochondrial for of DNA mtDNA and mtDNA of higher of DNA DNA mitochondrial mtDNA In mtDNA and mtDNA and an mitochondrial mtDNA and in degradation of mtDNA DNA mitochondrial DNA is by of In of mtDNA by of mtDNA in and mitochondrial DNA is by of and DNA in mtDNA and mitochondrial of mitochondrial for of DNA in DNA mtDNA of and DNA in mtDNA and mitochondrial an DNA in mtDNA and mitochondrial of mitochondrial for of DNA of and of DNA is in mtDNA degradation of multiple mtDNA mitochondrial DNA is by of of of DNA is by that in of mitochondrial for of DNA that DNA degradation by mitochondrial by of in in mtDNA and mitochondrial mitochondrial mtDNA mtDNA and mtDNA of in DNA mtDNA of of DNA in mtDNA and mtDNA of and in mitochondrial mtDNA DNA are of of mtDNA degradation in of mtDNA of mitochondrial and cellular and of and of that and in an in DNA and by A in and of of and for of and in mtDNA degradation of by and of and and of DNA of and are in in and that is which is in in of DNA degradation by mitochondrial higher of and higher of that in of that an for of that of DNA and in and higher of of DNA that in of of of an higher of for and of for in and in in of for of of in an higher in an in and for are higher and are in in is of of an of an of A in of by of in of is of for that and that of is of of and for of of of are of of for for and for of of for and of for of an of of for and of of of for of mitochondrial are are of in DNA in in of of is by and is by in and DNA of of DNA and in of that of in which in of of of of of of of that in of and that in of is DNA of DNA of of of and of and is mitochondrial of for DNA of and of higher by for and for in A and of higher of by of for DNA by of DNA and by of and that is of mitochondrial for of DNA of in of and of and and of and which in that is of and and is higher that of DNA that higher in an higher of for DNA by of of of and is in multiple of and multiple in in that in of for and for and of is that higher for for of are","journal":"Journal of Biological Chemistry","year":2022,"id":278763,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9446,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":875361,"name":"Wenyan Xu","orcid":"0000-0003-2034-2828","position":1,"is_corresponding":false},{"id":690400,"name":"Linlin Zhao","orcid":"0000-0002-8821-4198","position":2,"is_corresponding":false},{"id":951343,"name":"Kathleen M. 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