{"doi":"10.1016/j.jbc.2022.102275","title":"The oxidoreductase CLIC4 is required to maintain mitochondrial function and resistance to exogenous oxidants in breast cancer cells","abstract":"-treated control and CLIC4-null cells revealed upregulation of genes associated with ROS-induced apoptosis and downregulation of genes that sustain mitochondrial functions. Accordingly, tumors that formed from transplantation of CLIC4-deficient 6DT1 cells were highly necrotic. These results highlight a critical role for CLIC4 in maintaining redox-homeostasis and mitochondrial functions in 6DT1 cells. Our findings also raise the possibility of targeting CLIC4 to increase cancer cell sensitivity to chemotherapeutic drugs that are based on elevating ROS in cancer cells.","journal":"Journal of Biological Chemistry","year":2022,"id":264305,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":913002,"name":"Vanesa C. Sanchez","orcid":"0000-0002-8580-3480","position":1,"is_corresponding":false},{"id":690998,"name":"Hualong Yan","orcid":"0000-0003-1676-9140","position":2,"is_corresponding":false},{"id":623636,"name":"Christophe Cataisson","orcid":"0000-0003-2600-1573","position":3,"is_corresponding":false},{"id":271849,"name":"Aleksandra M. Michalowski","orcid":"0000-0001-9259-6101","position":4,"is_corresponding":false},{"id":271844,"name":"Howard H. Yang","orcid":"0000-0002-9291-631X","position":5,"is_corresponding":false},{"id":789795,"name":"Luowei Li","orcid":"0000-0002-1502-238X","position":6,"is_corresponding":false},{"id":271853,"name":"Maxwell P. Lee","orcid":"0000-0003-3738-1292","position":7,"is_corresponding":false},{"id":809997,"name":"Jing Huang","orcid":"0000-0002-0814-838X","position":8,"is_corresponding":false},{"id":623637,"name":"Stuart H. Yuspa","orcid":"0000-0003-4785-337X","position":9,"is_corresponding":false},{"id":922364,"name":"Heba Al Khamici","orcid":null,"position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:26:37.567338Z","pmid":"35863434","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}