{"doi":"10.1016/j.jbc.2022.102241","title":"Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration","abstract":"Malaria and other apicomplexan-caused diseases affect millions of humans, agricultural animals, and pets. Cell traversal is a common feature used by multiple apicomplexan parasites to migrate through host cells and can be exploited to develop therapeutics against these deadly parasites. Here, we provide insights into the mechanism of the Cell-traversal and a apicomplexan parasites and to to traversal of parasites through the of and the mechanism of is and is by a to to into of is a we is a of a of and and the mechanism of and other apicomplexan parasites the of other Malaria and other apicomplexan-caused diseases affect millions of humans, agricultural animals, and pets. Cell traversal is a common feature used by multiple apicomplexan parasites to migrate through host cells and can be exploited to develop therapeutics against these deadly parasites. Here, we provide insights into the mechanism of the Cell-traversal and a apicomplexan parasites and to to traversal of parasites through the of and the mechanism of is and is by a to to into of is a we is a of a of and and the mechanism of and other apicomplexan parasites the of other parasites a of and affect millions of and agricultural of the parasites the the and of a and can the of Cell by a and and of these the and and Malaria parasites and common the of a a and Cell traversal is common feature by apicomplexan parasites. to of the host and the Cell-traversal and Cell and traversal the of is is traversal the host and the is apicomplexan parasites the of of the a and the to migrate through a to and is a of by of and and and against the against and against the against against and and the of parasites and the host and the of a and of the other the of a the the and the the of to and the of the host the of the and into the is of the of of we the into a and and the the is and to and and and and a and the a of by a other of to and provide to the the and and the the of the the we and a the a the insights the mechanism of and apicomplexan is the the and to and into the of host the of we the and and and to and these a by a to a and the of and the the to the of the a of a the and a of to the the and the the a affect the of of the of the is the of the the of the and a of and and of the of and by of the of the the of the the the the of the the the of the and the and of of the be the and and the the of a of and the is these the of the and the to a the the a of and and the of the the to of a the these the to to the a of and is is a the of we the by and can be by and into the the of the and to the of the the of the of is the of of the is by of a the is other and a we provide to is of is a the of apicomplexan parasites and of the is of and the and the of the a a the of Cell-traversal and to a to the a to the the the a the a and and to the is to provide to into the of the host of the a to the to the we a of of the is the the of to the of and the the a a to and a of the into a the and these the is a the the of affect a of of is to the of and of and and to the the and the of the and multiple a the of the to the the is to the Cell-traversal and the of we and and a by a of the the of the and and and to and the a of a the of of these to and the and of of and the the is the of the the of the the the of and of and to the the and the of the a of to of and of used and a of the a of to the to the to of is a the of of the Cell-traversal and into the and a of the and the of and the of these the and we to these affect the and of the we to the the of and the of to of to the affect the the of the we the of and the and a can the of to of to the the affect to a of to the and and of the of and of apicomplexan-caused diseases and millions of the of a the and parasites the and host a to to to the of of and of apicomplexan and traversal and and a to and is and a can to and a of a a and to into the of is the to a to to the is by a and is by to and through the of a a to we the of is to and the we a of through of of b","journal":"Journal of Biological Chemistry","year":2022,"id":281505,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274905,"name":"John R. Jimah","orcid":"0000-0003-2835-433X","position":1,"is_corresponding":false},{"id":240295,"name":"Santosh A. Misal","orcid":"0000-0002-8835-0130","position":2,"is_corresponding":false},{"id":568285,"name":"Nichole D. Salinas","orcid":"0000-0003-4105-3718","position":3,"is_corresponding":false},{"id":285307,"name":"Michal Fried","orcid":"0000-0002-5478-6526","position":4,"is_corresponding":false},{"id":424245,"name":"Paul H. Schlesinger","orcid":"0000-0003-3268-7401","position":5,"is_corresponding":false},{"id":246796,"name":"Niraj H. Tolia","orcid":"0000-0002-2689-1337","position":6,"is_corresponding":false},{"id":246791,"name":"Hirdesh Kumar","orcid":"0000-0002-8488-3001","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:29:11.698554Z","pmid":"35809642","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}