{"doi":"10.1016/j.jbc.2022.102159","title":"Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation","abstract":"H]triolein showed a marked increase in intestinal uptake and secretion, whereas hepatic production and clearance of triglyceride-rich lipoproteins did not differ from wildtype controls. Uptake of dietary triolein was also elevated in brown adipose tissue (BAT), and notable increases in beige adipose tissue occurred, resulting in hyperthermia, hyperphagia, hyperdipsia, and increased energy expenditure. Furthermore, fasted MPS IIIa mice remained hyperthermic when subjected to low temperature but became cachexic and profoundly hypothermic when treated with a lipolytic inhibitor. We demonstrated that the reliance on increased lipid fueling of BAT was driven by a reduced ability to generate energy from stored lipids within the depot. These alterations arose from impaired autophagosome-lysosome fusion, resulting in increased mitochondria content in beige and BAT. Finally, we show that increased mitochondria content in BAT and postprandial dyslipidemia was partially reversed upon 5-week treatment with recombinant sulfamidase. We hypothesize that increased BAT activity and persistent increases in energy demand in MPS IIIa mice contribute to the negative energy balance observed in patients with MPS IIIa.","journal":"Journal of Biological Chemistry","year":2022,"id":289359,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":971454,"name":"William C. Lamanna","orcid":null,"position":1,"is_corresponding":false},{"id":970956,"name":"Chrissa A. Dwyer","orcid":"0000-0003-4565-2558","position":2,"is_corresponding":false},{"id":106533,"name":"Daniel R. Sandoval","orcid":"0000-0002-7938-315X","position":3,"is_corresponding":false},{"id":297171,"name":"Ariane Pessentheiner","orcid":"0000-0002-5010-9528","position":4,"is_corresponding":false},{"id":913348,"name":"Norah Al-Azzam","orcid":"0000-0002-8960-8236","position":5,"is_corresponding":false},{"id":971455,"name":"Stéphane Sarrazin","orcid":null,"position":6,"is_corresponding":false},{"id":971456,"name":"Jon C. Gonzales","orcid":null,"position":7,"is_corresponding":false},{"id":754553,"name":"Shih‐hsin Kan","orcid":"0000-0003-0209-4963","position":8,"is_corresponding":false},{"id":692643,"name":"Alexander Y. Andreyev","orcid":"0000-0002-9246-9943","position":9,"is_corresponding":false},{"id":751547,"name":"Nicholas Schultheis","orcid":null,"position":10,"is_corresponding":false},{"id":106542,"name":"Bryan E. Thacker","orcid":"0000-0003-0517-0810","position":11,"is_corresponding":false},{"id":106543,"name":"Charles A. Glass","orcid":"0000-0001-5297-5975","position":12,"is_corresponding":false},{"id":471360,"name":"Patricia Dickson","orcid":"0000-0003-3467-8488","position":13,"is_corresponding":false},{"id":360764,"name":"Raymond Wang","orcid":"0000-0001-6494-7613","position":14,"is_corresponding":false},{"id":750784,"name":"Scott B. Selleck","orcid":"0000-0001-6036-8542","position":15,"is_corresponding":false},{"id":106562,"name":"Jeffrey D. Esko","orcid":"0000-0001-8322-1834","position":16,"is_corresponding":false},{"id":106556,"name":"Philip L.S.M. Gordts","orcid":"0000-0001-7224-4328","position":17,"is_corresponding":false},{"id":970955,"name":"Miguel Tillo","orcid":"0000-0002-2024-1499","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:30:22.686776Z","pmid":"35750212","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}