{"doi":"10.1016/j.jbc.2022.101994","title":"Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII","abstract":"and TGF-β for binding to TβRI and TβRII, respectively. The solution structure of TGM-D3 revealed that TGM adopts a CCP-like fold but is also modified to allow the C-terminal strand to diverge, leading to an expansion of the domain and opening potential interaction surfaces. TGM-D3 also incorporates a long structurally ordered hypervariable loop, adding further potential interaction sites. Through NMR shift perturbations and binding studies of TGM-D3 and TβRII variants, TGM-D3 was shown to occupy the same site of TβRII as bound by TGF-β using both a novel interaction surface and the hypervariable loop. These results, together with the identification of other secreted CCP-like proteins with immunomodulatory activity in H. polygyrus, suggest that TGM is part of a larger family of evolutionarily plastic parasite effector molecules that mediate novel interactions with their host.","journal":"Journal of Biological Chemistry","year":2022,"id":244859,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":568782,"name":"Chang‐Hyeock Byeon","orcid":"0000-0001-9997-7708","position":1,"is_corresponding":false},{"id":567444,"name":"Cynthia S. Hinck","orcid":"0000-0002-2163-9378","position":2,"is_corresponding":false},{"id":878724,"name":"Kyle T. Cunningham","orcid":"0000-0002-2171-0277","position":3,"is_corresponding":false},{"id":878725,"name":"Tiffany Campion","orcid":"0009-0002-4010-0762","position":4,"is_corresponding":false},{"id":568783,"name":"Danielle J. Smyth","orcid":"0000-0001-6080-2679","position":5,"is_corresponding":false},{"id":636919,"name":"Rick M. Maizels","orcid":"0000-0003-3216-1944","position":6,"is_corresponding":false},{"id":398270,"name":"Andrew P. Hinck","orcid":"0000-0003-3320-8054","position":7,"is_corresponding":false},{"id":568781,"name":"Ananya Mukundan","orcid":"0000-0003-1161-4158","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T00:23:30.364338Z","pmid":"35500648","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}