{"doi":"10.1016/j.jbc.2022.101977","title":"Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase","abstract":"The posttranslational regulation of the neuronal proteome is critical for brain homeostasis but becomes dysregulated in the aged or diseased brain, in which abnormal posttranslational modifications (PTMs) are frequently observed. While the full extent of modified substrates that comprise the “PTM-ome” are slowly emerging, how the upstream enzymes catalyzing these processes are regulated themselves is not well understood, particularly in the context of neurodegeneration. Here, we describe the reciprocal regulation of a kinase, the microtubule affinity-regulating kinase 2 (MARK2), enzymes in the of that kinase a reciprocal a kinase which for how is substrates that the posttranslational of the enzymes The posttranslational regulation of the neuronal proteome is critical for brain homeostasis but becomes dysregulated in the aged or diseased brain, in which abnormal posttranslational modifications (PTMs) are frequently observed. While the full extent of modified substrates that comprise the “PTM-ome” are slowly emerging, how the upstream enzymes catalyzing these processes are regulated themselves is not well understood, particularly in the context of neurodegeneration. Here, we describe the reciprocal regulation of a kinase, the microtubule affinity-regulating kinase 2 (MARK2), enzymes in the of that kinase a reciprocal a kinase which for how is substrates that the posttranslational of the enzymes of posttranslational modifications (PTMs) a posttranslational in the of in the of of the of the of modifications in in a of the or of a is the regulation of in which of modifications in in in brain the brain the of but in brain of the of in the extent which substrates are regulated in the brain is not well of the of is the of of that are modified modifications of for brain in for of modifications the of modifications in modifications of in modifications or in that is not but is in the diseased these that a of or are is but a regulated in in kinase microtubule of kinase a critical in becomes a for is in in in is critical for in the of modifications the of that of the in is a critical in of are The of of of is of in brain a of of in of or of is is in in microtubule or that the enzymes that regulation themselves becomes a critical in the context of the diseased affinity-regulating a of in for regulation of in affinity-regulating are for kinase the of the of the kinase in brain of in of the of the is which the a kinase, the kinase that a critical upstream substrates well is but we that are substrates of The of of in the of the of the neuronal in in the context of The of that substrates modifications in of the of a kinase enzymes are regulated for Here, we that in a reciprocal that that the a that are we we in a of a that substrates in the of a a a kinase, the kinase of that is in of in which a of we the we in the of or the a that is in the a a a which not we that the of in the a that or but not the the or a of a a of in The that the we a but the of for we the the is a for the of that of kinase in the of are in the in the or of a of in the of or for the in microtubule affinity-regulating kinase how we of a of but we of is not is of the of of kinase for how we the we a a of we that particularly the the the the that we a in a in which is kinase the that in a in which the of is that The of kinase kinase in of kinase is The of in the of kinase kinase we the reciprocal which we in in which the in the of in the of of the a the is a in the or of the in for The in the of is the which is in that is in a in the the of the in the the the that the in the a microtubule affinity-regulating kinase the in a we that in we the of in the of While in the of The the of the the in that are we or that in the of the of the the the in the that kinase in the of or in the of of which in the of are in a or in the or of in The the that a the in in in the of a of the are in in kinase in the or of of microtubule affinity-regulating kinase posttranslational the of the the of","journal":"Journal of Biological Chemistry","year":2022,"id":284801,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":280528,"name":"Jui‐Heng Tseng","orcid":"0000-0002-9036-9121","position":1,"is_corresponding":false},{"id":532736,"name":"Camryn Isemann","orcid":null,"position":2,"is_corresponding":false},{"id":701951,"name":"Xu Tian","orcid":"0009-0002-2109-9866","position":3,"is_corresponding":false},{"id":280529,"name":"Youjun Chen","orcid":"0000-0002-6484-2325","position":4,"is_corresponding":false},{"id":397771,"name":"Laura E. Herring","orcid":"0000-0003-4496-7312","position":5,"is_corresponding":false},{"id":280536,"name":"Todd J. Cohen","orcid":"0000-0002-4099-0278","position":6,"is_corresponding":false},{"id":280531,"name":"Zarin Tabassum","orcid":"0000-0001-9007-2566","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T00:29:36.828109Z","pmid":"35469920","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}