{"doi":"10.1016/j.jbc.2022.101900","title":"Sialoglycan-binding patterns of bacterial AB5 toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits","abstract":"pentamers to a sialoglycan microarray, with sialic acid (Sia) preferences corresponding to those prominently expressed by various hosts, for example, N-acetylneuraminic acid (Neu5Ac; prominent in humans) or N-glycolylneuraminic acid (Neu5Gc; prominent in ruminant mammals and rodents). Here, we report that A subunit phylogeny evolved independently of B subunits and suggest a future B subunit nomenclature based on bacterial species names. We also found via phylogenetic analysis of B subunits, which bind Sias, that homologous molecules show poor correlation with species phylogeny. These data indicate ongoing lateral gene transfers between species, including mixing of A and B subunits. Consistent with much broader host range of Y. pestis, we show that YpeB recognizes all mammalian Sia types, except for 4-O-acetylated ones. Notably, YpeB alone causes dose-dependent cytotoxicity, which is abolished by a mutation (Y77F) eliminating Sia recognition, suggesting that cell proliferation and death are promoted via lectin-like crosslinking of cell surface sialoglycoconjugates. These findings help explain the host range of Y. pestis and could be important for pathogenesis. Overall, our data indicate ongoing rapid evolution of both host Sias and pathogen toxin-binding properties.","journal":"Journal of Biological Chemistry","year":2022,"id":271605,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":501537,"name":"Aniruddha Sasmal","orcid":"0000-0001-5446-8192","position":1,"is_corresponding":false},{"id":814861,"name":"Zahra Khedri","orcid":null,"position":2,"is_corresponding":false},{"id":814862,"name":"Patrick Secrest","orcid":null,"position":3,"is_corresponding":false},{"id":814460,"name":"Andrea Verhagen","orcid":"0000-0002-0535-4006","position":4,"is_corresponding":false},{"id":671262,"name":"Saurabh Srivastava","orcid":"0000-0003-4610-1790","position":5,"is_corresponding":false},{"id":400412,"name":"Nissi Varki","orcid":"0000-0001-9839-1254","position":6,"is_corresponding":false},{"id":313621,"name":"Xi Chen","orcid":"0000-0002-3160-614X","position":7,"is_corresponding":false},{"id":313874,"name":"Hai Yu","orcid":"0000-0002-4378-0532","position":8,"is_corresponding":false},{"id":826646,"name":"Travis Beddoe","orcid":"0000-0003-4550-2277","position":9,"is_corresponding":false},{"id":305070,"name":"Adrienne W. Paton","orcid":"0000-0002-2996-5733","position":10,"is_corresponding":false},{"id":305071,"name":"James C. Paton","orcid":"0000-0001-9807-5278","position":11,"is_corresponding":false},{"id":313878,"name":"Ajit Varki","orcid":"0000-0002-2206-975X","position":12,"is_corresponding":false},{"id":303706,"name":"Naazneen Khan","orcid":"0000-0002-4386-1703","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T00:27:39.717534Z","pmid":"35398357","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}