{"doi":"10.1016/j.jbc.2022.101876","title":"Entecavir competitively inhibits deoxyguanosine and deoxyadenosine phosphorylation in isolated mitochondria and the perfused rat heart","abstract":"Deoxyguanosine kinase (dGK) is reported responsible for the phosphorylation of deoxyadenosine (dA) and deoxyguanosine (dG) in the mitochondrial purine salvage pathway. Antiviral nucleoside analogs known as nucleoside reverse transcriptase inhibitors (NRTIs) must be phosphorylated for the the purine analogs be inhibitors of of the phosphorylation of and in the and for phosphorylation of and the phosphorylation of of and and inhibitors of phosphorylation of and the phosphorylation of and and the phosphorylation of the the of phosphorylation of for and of in and phosphorylated and phosphorylation is and the of is in the phosphorylation of Deoxyguanosine kinase (dGK) is reported responsible for the phosphorylation of deoxyadenosine (dA) and deoxyguanosine (dG) in the mitochondrial purine salvage pathway. Antiviral nucleoside analogs known as nucleoside reverse transcriptase inhibitors (NRTIs) must be phosphorylated for the the purine analogs be inhibitors of of the phosphorylation of and in the and for phosphorylation of and the phosphorylation of of and and inhibitors of phosphorylation of and the phosphorylation of and and the phosphorylation of the the of phosphorylation of for and of in and phosphorylated and phosphorylation is and the of is in the phosphorylation of kinase and kinase and phosphorylation of and nucleoside analogs and kinase and deoxyguanosine kinase (dGK) mitochondrial and and is of and in be deoxyadenosine and deoxyguanosine and and of mitochondrial phosphorylation of of mitochondrial deoxyguanosine kinase and purine and of the kinase the mitochondrial in the mitochondrial salvage and of and mitochondrial in deoxyguanosine kinase deoxyguanosine kinase in the of mitochondrial be and in of deoxyguanosine of in mitochondrial of in in the in mitochondrial kinase in mitochondrial and the of is of in of kinase in and is and kinase of and of kinase of for is and in in the of and of mitochondrial of in the and reported and in deoxyguanosine kinase is of is and as as and in be and deoxyguanosine kinase in of in and of and mitochondrial deoxyguanosine kinase is for in in of of the of the and of the the of of deoxyguanosine kinase of of in be and in of deoxyguanosine of and of in be and in of deoxyguanosine of in mitochondrial mitochondrial and deoxyguanosine and as the the and in the in deoxyguanosine kinase of of as for mitochondrial in of as of deoxyadenosine of in of in as the the in the and the in the the is reverse transcriptase inhibitors (NRTIs) nucleoside of phosphorylated the salvage in and phosphorylation of and nucleoside analogs and of in of in the salvage mitochondrial and the of and the of in and in the for of of in for and nucleoside reverse transcriptase in the and of in the phosphorylation of and and the purine analogs phosphorylation of and and the of the and the and of and in and for the of and as as of and in the be of purine and and phosphorylation analogs the phosphorylation of and and for and phosphorylation of and nucleoside analogs and of mitochondrial deoxyguanosine kinase and purine and for of for the of the phosphorylation of the phosphorylation of for is in the of and is deoxyguanosine of in and of for the of and in is be and for in of and mitochondrial the of of of in reported is mitochondrial of mitochondrial is for of for of in mitochondrial be and for as for of be phosphorylated in the for the is phosphorylated in as the phosphorylation of and in the the purine salvage and the of in in mitochondrial in deoxyguanosine kinase mitochondrial kinase in mitochondrial of the of and nucleoside analogs and analogs and in and in for in the of and as in the be the of the of the phosphorylation of and for phosphorylation of and the phosphorylation of in and of and in the in the in phosphorylated and the of phosphorylated of the in mitochondrial and in the the of phosphorylation of the and of in of the phosphorylation in of in the and the and and of for as for and the as phosphorylated for as of of ","journal":"Journal of Biological Chemistry","year":2022,"id":295068,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9636,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":650346,"name":"Chia‐Heng Hsiung","orcid":"0000-0003-3542-587X","position":1,"is_corresponding":false},{"id":981097,"name":"Daniel G. Kesterson","orcid":null,"position":2,"is_corresponding":false},{"id":981098,"name":"Vasudeva Kamath","orcid":null,"position":3,"is_corresponding":false},{"id":980737,"name":"Edward E. McKee","orcid":"0000-0002-4467-7668","position":4,"is_corresponding":false},{"id":981096,"name":"Avery S. Ward","orcid":null,"position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T00:31:05.260069Z","pmid":"35358513","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}