{"doi":"10.1016/j.jbc.2021.101185","title":"ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium","abstract":"Very low-density lipoprotein receptor (VLDLR) is a multifunctional transmembrane protein. Beyond the function of the full-length VLDLR in lipid transport, the soluble ectodomain of VLDLR (sVLDLR) confers anti-inflammatory in of is the the a is in the of of of the in of in the in the VLDLR in in a of of in of the VLDLR a the of of Very low-density lipoprotein receptor (VLDLR) is a multifunctional transmembrane protein. Beyond the function of the full-length VLDLR in lipid transport, the soluble ectodomain of VLDLR (sVLDLR) confers anti-inflammatory in of is the the a is in the of of of the in of in the in the VLDLR in in a of of in of the VLDLR a the of of Very low-density lipoprotein receptor (VLDLR) is a multifunctional in the low-density lipoprotein receptor lipoprotein receptor is lipid in a in lipoprotein of the lipoprotein receptor Very lipoprotein receptor (VLDLR) is a in VLDLR the receptor in receptor is a receptor lipoprotein receptor (VLDLR) the the VLDLR ectodomain of the low-density lipoprotein Very lipoprotein a of the a the of in Very lipoprotein a of the low-density lipoprotein receptor of VLDLR ectodomain is VLDLR the of VLDLR is the full-length VLDLR VLDLR VLDLR the of the confers a ectodomain a of lipoprotein receptor in the the of lipoprotein receptor in a function of ectodomain of in the in soluble ectodomain of VLDLR (sVLDLR) is in the the the of lipoprotein receptor in is is VLDLR the ectodomain of transmembrane the ectodomain of in of the of transmembrane in the the of transmembrane the ectodomain in a ectodomain of in in ectodomain of in the of transmembrane in the in ectodomain of in is the of of the of the of in of of of in the a the lipid of the of of of of in the of of in the a the of of the lipid of in the of in the of in of the VLDLR the a in the the the VLDLR a the in of the VLDLR the the of the VLDLR VLDLR the of of a VLDLR the VLDLR the of a the of of lipoprotein receptor in is the the of the of the VLDLR a of a in VLDLR VLDLR the the of ectodomain of in is a is the the of of of the of the is in of the of the in VLDLR in a VLDLR in the of VLDLR of in the the a of in VLDLR a of VLDLR in the VLDLR of of VLDLR of in full-length in the of of in VLDLR in in of in in of in the in the full-length VLDLR in of of in in of of in VLDLR in in of a a of soluble ectodomain of low-density lipoprotein VLDLR of of VLDLR of VLDLR of the VLDLR VLDLR of the of in of in VLDLR the VLDLR in of the in the in in the VLDLR VLDLR of of in the in of the of of in VLDLR in in of of in in in of of in VLDLR in in of a a of soluble ectodomain of low-density lipoprotein VLDLR a a the of the of VLDLR of the of VLDLR of in the in the of VLDLR in of the of VLDLR in in a of low-density lipoprotein VLDLR lipid the full-length VLDLR a in lipid in lipoprotein receptor VLDLR lipid lipid in the lipid in the lipid in of in a the of the in in in the VLDLR the lipid the of lipid lipid of lipid in of lipid the in the of in of in a of low-density lipoprotein the VLDLR in the of VLDLR in of the a in the of the function of the the of in the of the of in the in the in in the the the in VLDLR of VLDLR in the of the of of in the of of in the in of of full-length VLDLR in the of VLDLR in the in a soluble ectodomain of low-density lipoprotein VLDLR in a of the of in in the the VLDLR the of the VLDLR the of in of VLDLR in in VLDLR the of in a of in a the VLDLR in VLDLR in a VLDLR in a a the of of in in VLDLR in VLDLR in of in the full-length VLDLR in in of of in VLDLR in the the full-length VLDLR a of in VLDLR in in of a a of low-density lipoprotein VLDLR VLDLR function VLDLR the in in the of a VLDLR VLDLR in the of of of in the a is of the the of the of in the is in in is the of in of the the of VLDLR in in the VLDLR in the of in of in a the of of of VLDLR of of in VLDLR in of in in VLDLR in in of in of in in of in of in of of in of in of a of soluble ectodomain of low-density lipoprotein VLDLR in the the in a the of the the of in a of the in a of i","journal":"Journal of Biological Chemistry","year":2021,"id":194141,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471596,"name":"Yusuke Takahashi","orcid":"0000-0002-5436-2942","position":1,"is_corresponding":false},{"id":759566,"name":"Wenjing Wu","orcid":"0000-0001-8437-3370","position":2,"is_corresponding":false},{"id":666143,"name":"Wentao Liang","orcid":"0000-0002-0609-6280","position":3,"is_corresponding":false},{"id":453596,"name":"Jianglei Chen","orcid":"0000-0001-8147-3894","position":4,"is_corresponding":false},{"id":356278,"name":"Dibyendu Chakraborty","orcid":"0000-0003-3934-3249","position":5,"is_corresponding":false},{"id":763937,"name":"Yangxiong Li","orcid":null,"position":6,"is_corresponding":false},{"id":763938,"name":"Yanhong Du","orcid":null,"position":7,"is_corresponding":false},{"id":472437,"name":"Siribhinya Benyajati","orcid":null,"position":8,"is_corresponding":false},{"id":279641,"name":"Jian‐xing Ma","orcid":"0000-0001-8815-1716","position":9,"is_corresponding":false},{"id":759565,"name":"Xiang Ma","orcid":"0000-0002-2307-1309","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:49:55.282992Z","pmid":"34509473","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}