{"doi":"10.1016/j.jbc.2021.101173","title":"Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β","abstract":"Bisphenol A and its derivatives are recognized as endocrine disruptors based on their complex effects on estrogen receptor (ER) signaling. While the effects of bisphenol derivatives on ERα have been thoroughly evaluated, how these chemicals affect ERβ signaling is less well understood. Herein, we sought to identify novel ERβ ligands using to of bisphenol of the as ERα and ERβ of these and ERβ to the of ERβ to the on the of the as using and ERβ the of the and of ERβ and these as is the to bisphenol derivatives as the of and their to as endocrine Bisphenol A and its derivatives are recognized as endocrine disruptors based on their complex effects on estrogen receptor (ER) signaling. While the effects of bisphenol derivatives on ERα have been thoroughly evaluated, how these chemicals affect ERβ signaling is less well understood. Herein, we sought to identify novel ERβ ligands using to of bisphenol of the as ERα and ERβ of these and ERβ to the of ERβ to the on the of the as using and ERβ the of the and of ERβ and these as is the to bisphenol derivatives as the of and their to as endocrine are of the receptor of to to have been and the receptor and the of these recognized as of receptor and are receptor signaling as novel and ERα and have the and of novel estrogen receptor and ERα have been estrogen and ERα are of ERα to and to ERβ ERα are of and of estrogen receptor ERα and ERβ the to ERα ERβ the of the estrogen and of and of estrogen and on ERα and ERβ are their and are of the receptor to have of bisphenol A as the effects on the on the and effects of bisphenol A is as and its effects on and have to of and to its derivatives have been to and and and these derivatives are as A of the and of bisphenol A and have been the A of the and of bisphenol A and on of bisphenol A and bisphenol is as to of bisphenol the and the have been Bisphenol the and and and of bisphenol the and have been to of bisphenol and of and and the bisphenol as bisphenol bisphenol is of the of of the and bisphenol A of and is to and and and of A novel of chemicals on and its derivatives have the on its estrogen receptor of receptor the of endocrine disruptors the on the of the of have as to the been of bisphenol A and using ERβ are of their signaling chemicals estrogen receptor and of ERα and ERβ have and the ERα and ERβ have have of and of the and of estrogen and to ERα to ERα its are of and ERα and ERβ ERβ ERα and ERβ using Bisphenol is the estrogen receptor ERα and and of bisphenol A and ERβ and and of bisphenol A and of ligands estrogen While have ERα and and and of bisphenol A and of ligands estrogen the the of and ERβ are well we the bisphenol is we the of and to ERβ and novel of the based on the of to is the to the of the bisphenol ERα and of bisphenol derivatives and using of these bisphenol derivatives have been on of bisphenol A and and are bisphenol derivatives ERβ and the ERβ of and ERα of of the derivatives ERβ of ERα of and to ERβ of to the and ERβ to ERβ bisphenol and to to of the chemicals to ERα and the derivatives ERβ to ERα ERβ bisphenol derivatives to ERα of novel receptor and their ERβ to the ERα of novel receptor and ERβ of and to ERα of novel receptor and is and to ERβ is and their ERβ of Bisphenol derivatives ERβ of derivatives of novel receptor and using as the ERβ and ERα we the the ERβ and ERα of the ERα and ERβ their using and the the ligands and ERβ ERα and ERα and of receptor the are and the of the ERα and ERβ and and ERα and ERβ and these ERα is to ligands the the ligands of the ligands the ERβ the ERα of derivatives on ERα and ERα and ERβ the of derivatives to ERβ the of ERα and ERβ are is as the of the bisphenol bisphenol estrogen and to using to ERβ and bisphenol derivatives of is and the of of are the ERβ of the the the its of and bisphenol of the of While as been to as ERα of bisphenol and of and are to on the the is ERβ bisphenol and as to of the of and ERα and these ERβ ERα and and of bisphenol A and of ligands estrogen bisph","journal":"Journal of Biological Chemistry","year":2021,"id":168783,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":375069,"name":"Takahiro Masuya","orcid":null,"position":1,"is_corresponding":false},{"id":698871,"name":"Mari Hosose","orcid":null,"position":2,"is_corresponding":false},{"id":698872,"name":"Koki Tagawa","orcid":null,"position":3,"is_corresponding":false},{"id":698873,"name":"Tomoka Ishibashi","orcid":null,"position":4,"is_corresponding":false},{"id":698874,"name":"Keitaro Suyama","orcid":null,"position":5,"is_corresponding":false},{"id":698378,"name":"Takeru Nose","orcid":"0000-0001-9771-7267","position":6,"is_corresponding":false},{"id":7362,"name":"Eiji Yoshihara","orcid":"0000-0001-6324-6495","position":7,"is_corresponding":false},{"id":80487,"name":"Michael Downes","orcid":"0000-0002-6351-9585","position":8,"is_corresponding":false},{"id":80488,"name":"Ronald M. Evans","orcid":"0000-0002-9986-5965","position":9,"is_corresponding":false},{"id":698379,"name":"Ayami Matsushima","orcid":"0000-0001-9751-577X","position":10,"is_corresponding":false},{"id":698870,"name":"Masaki Iwamoto","orcid":null,"position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T23:46:06.853307Z","pmid":"34499926","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}