{"doi":"10.1016/j.jbc.2021.100748","title":"How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 2","abstract":"In part 1 of this remarkable collection, we told you the story of The Protein Data Bank (PDB) (1Berman H.M. Gierasch L.M. How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1.J. Biol. Chem. 2021; 296: 100608Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar), which was founded 50 years ago, and we illustrated the breadth of the science contained within it with ten informative review articles. The second half of this collection is a continuation of our celebrations to mark this momentous anniversary. Part 2 provides eight more superb articles describing how the PDB has influenced biology over the course of the last half-century and how biology has fueled the deposition of impactful structures in the PDB. Here are some brief synopses of the articles you will enjoy in part 2! In part 1 of this remarkable collection, we told you the story of The Protein Data Bank (PDB) (1Berman H.M. Gierasch L.M. How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1.J. Biol. Chem. 2021; 296: 100608Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar), which was founded 50 years ago, and we illustrated the breadth of the science contained within it with ten informative review articles. The second half of this collection is a continuation of our celebrations to mark this momentous anniversary. Part 2 provides eight more superb articles describing how the PDB has influenced biology over the course of the last half-century and how biology has fueled the deposition of impactful structures in the PDB. Here are some brief synopses of the articles you will enjoy in part 2! Our understanding of cellular signaling is dependent on the knowledge of key protein structures. In their review, Susan S. Taylor (University of California, San Diego) and colleagues use cAMP-dependent protein kinase as a model system to show us the many levels of detail of the structural basis of signaling (2Taylor S.S. Wu J. Bruystens J.G.H. Del Rio J.C. Lu T.-W. Kornev A.P. Ten Eyck L.F. From structure to the dynamic regulation of a molecular switch: A journey over three decades.J. Biol. Chem. 2021; 296: 100746Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar). The authors describe the landmark structure of the catalytic subunit of PKA and then explore how the kinase domain is packaged in an inactive state by the cAMP binding regulatory subunits. The review also captures the importance of understanding crystal packing, using multiple structural determination methods, and thinking outside the box. Transcriptional regulation is fundamental to cellular homeostasis, coordinating responses to a wide array of physiological signals. In her review, Cynthia Wolberger (The Johns Hopkins University School of Medicine) focuses on how the structures of protein–DNA complexes have provided insights into regulation of transcription (3Wolberger C. How structural biology transformed studies of transcription regulation.J. Biol. Chem. 2021; 296: 100741Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar). She describes some of the earliest structures that were determined in the 1980s and explores the structural basis for the remarkable diversity of sequence-specific binding modes. She then discusses the multimeric complexes that are utilized in eukaryotic systems and the ability of cryo-electron microscopy to enable visualization of very large macromolecular complexes with ever-increasing molecular detail, now facilitating the structural understanding of large transcription and elongation machines. The field of structural immunology was born 50 years ago with the first determination of antibody structures. In their review, Ian Wilson (The Scripps Research Institute) and his colleague Robyn Stanfield trace how structures were pivotal to our understanding of antibody–antigen interactions and revealed the diversity of the antigen receptors and the antigen","journal":"Journal of Biological Chemistry","year":2021,"id":201155,"datarank":0.42808103032037514,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.11616479906839972,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.11616479906839972,"corpus_percentile":56.50963100487352,"corpus_rank":5623,"citation_count":7,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6429,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":2156,"name":"Helen M. 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