{"doi":"10.1016/j.jaut.2025.103517","title":"Humoral correlates of clinical response to thymectomy in myasthenia gravis","abstract":"Mechanisms by which thymectomy confers its clinical benefit in patients with AChR-antibody (Ab) positive myasthenia gravis (MG) remain poorly understood. We used a systems-level approach combined with high-dimensional characterization of Ab-associated immune features to identify Ab-features that track with clinical response to thymectomy in 78 patients with AChR-Ab positive MG, recruited during the MGTX trial, an NIH-sponsored randomized, controlled study of thymectomy plus prednisone versus prednisone alone. Clinically meaningful improvement was defined as a change of at least 3 points on the quantitative MG scale at month 36 compared to baseline. AChR-specific immunoglobulin G (IgG) titers decreased in patients experiencing clinical improvement but remained stable in patients with poor response to therapy. Thymectomized patients showed an accelerated decline in AChR-specific IgG titers. At month 36, the frequency of digalactosylated and monosialylated total IgG Fc-glycans was increased in thymectomized responders compared to non-responders. Fc-glycosylation profiles were unchanged in prednisone only treated patients with or without clinically meaningful improvement. Clinical benefit achieved by thymectomy is strongly associated with an anti-inflammatory IgG Fc-glycosylation profile.","journal":"Journal of Autoimmunity","year":2025,"id":537571,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9631,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1423788,"name":"Paula Terroba-Navajas","orcid":null,"position":1,"is_corresponding":false},{"id":1423371,"name":"John Tzartos","orcid":"0000-0002-8153-5300","position":2,"is_corresponding":false},{"id":1423789,"name":"Ivana Duvnjak Orešković","orcid":null,"position":3,"is_corresponding":false},{"id":53119,"name":"Maja Pučić‐Baković","orcid":"0000-0003-0866-623X","position":4,"is_corresponding":false},{"id":53139,"name":"Gordan Lauc","orcid":"0000-0003-1840-9560","position":5,"is_corresponding":false},{"id":108364,"name":"Yannic C. Bartsch","orcid":"0000-0002-3844-3056","position":6,"is_corresponding":false},{"id":270884,"name":"Henry J. Kaminski","orcid":"0000-0002-8195-0141","position":7,"is_corresponding":false},{"id":707716,"name":"Jan D. Lünemann","orcid":"0000-0002-3007-708X","position":8,"is_corresponding":false},{"id":1423787,"name":"Carla Daiane Ferreira de Sousa","orcid":null,"position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:52:12.997494Z","pmid":"41411760","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}