{"doi":"10.1016/j.jamda.2023.06.015","title":"Consumption of Coffee, Tea, and Caffeine at Midlife, and the Risk of Physical Frailty in Late Life","abstract":"ObjectivesOur study evaluated the prospective association between the consumption of caffeine-containing beverages at midlife and the risk of physical frailty at late life within a population-based cohort of Chinese adults living in Singapore over a follow-up period of 20 years.DesignProspective cohort study.Setting and ParticipantsWe used data from 12,583 participants from the baseline and third follow-up interviews of the XXXXXXXXXXXXXXXX. Participants had a mean age of 53 years at baseline (1993–1998), and mean age of 73 years during the third follow-up (2014–2017).MethodsAt baseline, habitual consumption of caffeine-containing beverages was evaluated using a validated semi-quantitative food-frequency questionnaire. During the third follow-up, physical frailty was assessed using the modified Cardiovascular Health Study phenotype.ResultsCompared with non-daily drinkers, those who drank 4 or more cups of coffee daily had reduced odds of physical frailty (odds ratio [OR], 0.54; 95% CI, 0.38–0.76). Similarly, compared with those who hardly drank tea, participants who drank tea everyday also had reduced odds (OR, 0.82; 95% CI, 0.71–0.95). Total daily caffeine intake at midlife was associated with reduced likelihood of frailty at late life in a dose-response relationship (Ptrend < .001). Relative to their counterparts in the lowest quartile of daily caffeine intake (0–67.6 mg/d), participants in the highest quartile (223.0–910.4 mg/d) had an OR of 0.77 (95% CI, 0.66–0.91). Higher caffeine consumption was associated with lower likelihood of being in the slowest quintile for timed up-and-go (TUG) and weakest quintile for handgrip strength.Conclusions and ImplicationsIn this cohort of Chinese adults, higher consumption of caffeine at midlife, via coffee and tea, was associated with a reduced likelihood of physical frailty in late life.","journal":"Journal of the American Medical Directors Association","year":2023,"id":333986,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9197,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":741020,"name":"Huiqi Li","orcid":"0009-0008-2107-2835","position":1,"is_corresponding":false},{"id":703944,"name":"Wee Shiong Lim","orcid":"0000-0003-3975-7230","position":2,"is_corresponding":false},{"id":260003,"name":"Woon‐Puay Koh","orcid":"0000-0002-5674-6341","position":3,"is_corresponding":false},{"id":390742,"name":"Kevin Yiqiang Chua","orcid":"0000-0002-1338-0781","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:09:44.297718Z","pmid":"37488031","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}