{"doi":"10.1016/j.jamcollsurg.2021.02.002","title":"Trauma, Metabolomics, Outcomes, and Secrets of the Sphinx","abstract":"Trauma remains a leading cause of mortality in all age groups, with an increasing global impact as the population ages. 1 Rhee P. Joseph B. Pandit V. et al. Increasing trauma deaths in the United States. Ann Surg. 2014; 260: 13-21 Crossref PubMed Scopus (286) Google Scholar Advances in pre-hospital care, damage control surgery, and blood-based damage control resuscitation have led to significant improvement in initial survival from exsanguination after serious injury, 2 Holcomb J.B. Tilley B.C. Baraniuk S. et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015; 313: 471-482 Crossref PubMed Scopus (1160) Google Scholar but these patients often remain critically ill and are at risk for ongoing sequelae, including organ failure, 3 Kornblith L.Z. Robles A.J. Conroy A.S. et al. Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation. J Trauma Acute Care Surg. 2019; 87: 371-378 Crossref PubMed Scopus (5) Google Scholar development of chronic critical illness, 4 Nomellini V. Kaplan L.J. Sims C.A. Caldwell C.C. Chronic critical illness and persistent inflammation: what can we learn from the elderly, injured, septic, and malnourished?. Shock. 2018; 49: 4-14 Crossref PubMed Scopus (17) Google Scholar and late mortality after injury. 5 Callcut R.A. Kornblith L.Z. Conroy A.S. et al. The why and how our trauma patients die: A prospective Multicenter Western Trauma Association study. J Trauma Acute Care Surg. 2019; 86: 864870 Crossref Scopus (29) Google Scholar ,6 Callcut R.A. Wakam G. Conroy A.S. et al. Discovering the truth about life after discharge: Long-term trauma-related mortality. J Trauma Acute Care Surg. 2016; 80: 210-217 Crossref PubMed Scopus (16) Google Scholar Despite intensive ongoing efforts, many aspects of post-resuscitation physiology and metabolic function, and, more importantly, potential opportunities to improve outcomes, remain incompletely understood. Analysis of the Plasma Metabolome after Trauma, Novel Circulating Sphingolipid Signatures, and In-Hospital OutcomesJournal of the American College of SurgeonsVol. 232Issue 3PreviewTrauma is the leading cause of death and disability for individuals under age 55. Many severely injured trauma patients experience complicated clinical courses despite appropriate initial therapy. We sought to identify novel circulating metabolomic signatures associated with clinical outcomes following trauma. Full-Text PDF Open Access","journal":"Journal of the American College of Surgeons","year":2021,"id":224163,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":384621,"name":"Timothy A. Pritts","orcid":"0000-0003-2495-3255","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-18T23:54:18.470602Z","pmid":"33896480","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}