{"doi":"10.1016/j.jalz.2015.04.005","title":"Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014","abstract":"<h4>Introduction</h4>The Alzheimer's Disease Neuroimaging Initiative (ADNI) was established in 2004 to facilitate the development of effective treatments for Alzheimer's disease (AD) by validating biomarkers for AD clinical trials.<h4>Methods</h4>We searched for ADNI publications using established methods.<h4>Results</h4>ADNI has (1) developed standardized biomarkers for use in clinical trial subject selection and as surrogate outcome measures; (2) standardized protocols for use across multiple centers; (3) initiated worldwide ADNI; (4) inspired initiatives investigating traumatic brain injury and post-traumatic stress disorder in military populations, and depression, respectively, as an AD risk factor; (5) acted as a data-sharing model; (6) generated data used in over 600 publications, leading to the identification of novel AD risk alleles, and an understanding of the relationship between biomarkers and AD progression; and (7) inspired other public-private partnerships developing biomarkers for Parkinson's disease and multiple sclerosis.<h4>Discussion</h4>ADNI has made myriad impacts in its first decade. 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