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Initial CSF studies by the ADNI Biomarker Core revealed a pathological CSF biomarker signature of AD defined by the combination of Aβ1‐42 and total tau (T‐tau) that effectively delineates mild AD in the large multisite prospective clinical investigation conducted in ADNI. This signature appears to predict conversion from MCI to AD. Data fusion efforts across ADNI Cores generated a model for the temporal ordering of AD biomarkers which suggests that Aβ amyloid biomarkers become abnormal first, followed by changes in neurodegenerative biomarkers (CSF tau, F‐18 fluorodeoxyglucose‐positron emission tomography, magnetic resonance imaging) with the onset of clinical symptoms. The timing of these changes varies in individual patients due to genetic and environmental factors that increase or decrease an individual's resilience in response to progressive accumulations of AD pathologies. Further studies in ADNI will refine this model and render the biomarkers studied in ADNI more applicable to routine diagnosis and to clinical trials of disease modifying therapies.</jats:p></jats:sec>","journal":"Alzheimer's &amp; Dementia","year":2010,"id":595378,"datarank":0.8628858958238451,"base_score":5.752572638825633,"endowment":5.752572638825633,"self_citation_contribution":0.8628858958238451,"citation_network_contribution":0.0,"self_endowment_contribution":0.8628858958238451,"citer_contribution":0.0,"corpus_percentile":76.6,"corpus_rank":3051,"citation_count":314,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1524561,"name":"Hugo Vandeerstichele","orcid":null,"position":1,"is_corresponding":false},{"id":66393,"name":"Magdalena Korecka","orcid":null,"position":2,"is_corresponding":false},{"id":58511,"name":"Christopher M. 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