{"doi":"10.1016/j.jalz.2006.05.2345","title":"IC–101–06: Functional deactivation in midline posterior cortical regions correlates with severity of memory dysfunction in MCI and mild Alzheimer disease","abstract":null,"journal":"Alzheimer's & Dementia","year":2006,"id":639591,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1661835,"name":"Sriyesh Krishnan","orcid":null,"position":1,"is_corresponding":false},{"id":540985,"name":"Lihong Wang","orcid":"0009-0002-7085-301X","position":2,"is_corresponding":false},{"id":1661836,"name":"Melissa Slavin","orcid":null,"position":3,"is_corresponding":false},{"id":1661837,"name":"Steven Prince","orcid":null,"position":4,"is_corresponding":false},{"id":1011423,"name":"Thu Tran","orcid":"0000-0002-4875-7438","position":5,"is_corresponding":false},{"id":850244,"name":"Murali Doraiswamy","orcid":null,"position":6,"is_corresponding":false},{"id":66630,"name":"Jeffrey Petrella","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"IC–101–06: Functional deactivation in midline posterior cortical regions correlates with severity of memory dysfunction in MCI and mild Alzheimer disease","abstract":"Medial temporal lobe activation, as measured by functional magnetic resonance imaging (fMRI), has been proposed as a possible early marker of Alzheimer's disease (AD). Decreases in medial temporal lobe activation in AD have been well described, however findings in the mild cognitive impairment (MCI) population have been less consistent. The purpose of this study was to detect changes in functional brain activity in incipient AD across the entire brain using fMRI during a face–name associative memory encoding task. The paradigm involved encoding of novel face–name pairs and familiar face–name pairs which were presented to the subject within a blocked design for later retrieval. Thirty–four non–demented individuals with MCI, 13 patients with mild AD, and 28 healthy elderly controls participated in the study. The left hippocampus and right parahippocampal gyrus revealed decreased activation for novel vs familiar face–name encoding in AD, but not in the MCI group, whereas left fusiform gyrus showed decreased activation in MCI. Bilateral posterior cingulate cortex (PCC), including the precuneus, demonstrated “deactivation” in the healthy elderly controls. The magnitude of deactivation demonstrated a monotonic decrease from controls to MCI to AD in an ANCOVA analysis, using age as a covariate. Deactivation in the PCC also significantly correlated with score on the delayed portion of the California Verbal Learning Test (CVLT). Findings of decreased deactivation in the PCC are consistent with those of other studies indicating decreased default–mode activity in AD. Deactivation in the PCC could be a more sensitive and early fMRI marker of AD compared to activation in the MTL, which is less consistent in the prodromal stages of the disease. Current findings further support the hypothesis that default–mode activity in the PCC might be related to episodic memory processing, which is impaired in mild and prodromal AD.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W2097050859","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.14569757,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2006.05.2345","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2006.05.2345","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1552526006047340?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1552526006047340?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.jalz.2006.05.2345","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.jalz.2006.05.2345","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1016/j.jalz.2006.05.2345","host_type":"publisher"},{"url":"https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1016/j.jalz.2006.05.2345","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jalz.2006.05.2345","host_type":"journal"}],"fields_of_study":["Dementia and Cognitive Impairment Research"],"mesh_terms":[],"keywords":["Posterior cingulate","Precuneus","Fusiform gyrus","Default mode network","Functional magnetic resonance imaging","Temporal lobe","Parahippocampal gyrus","Psychology","Lingual gyrus","Neuroscience","Episodic memory","Audiology","Fusiform face area","Inferior temporal gyrus","Hippocampus","Medicine","Cognition","Face perception","Epilepsy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T00:54:50.360513Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}