{"doi":"10.1016/j.jaip.2023.12.006","title":"Dupilumab Improves Lung Function Parameters in Pediatric Type 2 Asthma: VOYAGE Study","abstract":"Background Uncontrolled asthma in growing children can impair lung growth that may lead to adverse complications in later life. Dupilumab, a human monoclonal antibody, blocks the shared receptor for IL-4 and IL-13, key drivers of type 2 inflammation. Objective To extensively evaluate the effect of dupilumab on lung function in children (6-11 years) with moderate-to-severe asthma enrolled in phase 3 LIBERTY ASTHMA VOYAGE (NCT02948959). Methods Children with asthma were randomized 2:1 to add-on dupilumab 100/200 mg by bodyweight or placebo every 2 weeks, for 52 weeks. We analyzed spirometry parameters in children with type 2 asthma (blood eosinophils ≥150 cells/μL or fractional exhaled nitric oxide [FeNO] ≥20 parts per billion [ppb] at baseline) and within subgroups defined by baseline blood eosinophils or FeNO values. Results A total of 116 (49%) dupilumab-treated children and 59 (52%) on placebo had impaired lung function (prebronchodilator percent-predicted forced expiratory volume in 1 second [ppFEV 1 ] <80%) at baseline. Dupilumab improved pre- and postbronchodilator ppFEV 1 as early as week 2, sustained for up to 52 weeks (least-squares mean difference vs placebo at week 52: 7.79 percentage points; 95% confidence interval [CI]: 4.36-11.22; P < .001 and 4.37 points; 95% CI: 0.95-7.78; P = .01, respectively). Sustained improvements were also observed in other lung function parameters, including pre- and postbronchodilator forced vital capacity (FVC), prebronchodilator forced expiratory flow, and FEV 1 /FVC ratio across all populations. Conclusions Dupilumab led to significant, sustained lung function improvements across a range of lung function measures in children (6-11 years) with uncontrolled, moderate-to-severe type 2 asthma.","journal":"The Journal of Allergy and Clinical Immunology In Practice","year":2023,"id":332979,"datarank":0.6974874103487645,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.21465603661853427,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.21465603661853427,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":21,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02948959"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":317019,"name":"Theresa W. Guilbert","orcid":"0000-0002-6932-712X","position":1,"is_corresponding":false},{"id":623161,"name":"Constance H. Katelaris","orcid":"0000-0002-4412-1336","position":2,"is_corresponding":false},{"id":254001,"name":"A. Deschildre","orcid":"0000-0003-2006-7221","position":3,"is_corresponding":false},{"id":11550,"name":"Wanda Phipatanakul","orcid":"0000-0001-8639-0473","position":4,"is_corresponding":false},{"id":527151,"name":"Dongfang Liu","orcid":"0000-0002-8801-2190","position":5,"is_corresponding":false},{"id":913609,"name":"Arman Altincatal","orcid":"0009-0003-6666-6227","position":6,"is_corresponding":false},{"id":843078,"name":"Leda Mannent","orcid":null,"position":7,"is_corresponding":false},{"id":622676,"name":"Nikhil Amin","orcid":null,"position":8,"is_corresponding":false},{"id":622675,"name":"Elizabeth Laws","orcid":null,"position":9,"is_corresponding":false},{"id":882026,"name":"Bolanle Akinlade","orcid":"0000-0003-2334-5717","position":10,"is_corresponding":false},{"id":841933,"name":"Juby A. Jacob‐Nara","orcid":"0000-0002-5372-8762","position":11,"is_corresponding":false},{"id":622669,"name":"Yamo Deniz","orcid":null,"position":12,"is_corresponding":false},{"id":627299,"name":"Paul J. Rowe","orcid":null,"position":13,"is_corresponding":false},{"id":314630,"name":"David J. Lederer","orcid":"0000-0001-5258-0228","position":14,"is_corresponding":false},{"id":526917,"name":"Megan Hardin","orcid":"0000-0001-7622-9598","position":15,"is_corresponding":false},{"id":110400,"name":"Leonard B. Bacharier","orcid":"0000-0003-0432-2704","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:09:35.125543Z","pmid":"38092225","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}