{"doi":"10.1016/j.jaip.2023.06.007","title":"Basophil Activation Test in Double-Sensitized Patients With Hymenoptera Venom Allergy: Additional Benefit of Component-Resolved Diagnostics","abstract":null,"journal":"The Journal of Allergy and Clinical Immunology: In Practice","year":2023,"id":659664,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1243210,"name":"Simon Blank","orcid":"0000-0002-5649-1078","position":1,"is_corresponding":false},{"id":1247258,"name":"Sabine Altrichter","orcid":"0000-0001-9955-385X","position":2,"is_corresponding":false},{"id":773001,"name":"Wolfram Hoetzenecker","orcid":"0000-0003-4710-0642","position":3,"is_corresponding":false},{"id":28655,"name":"Knut Brockow","orcid":"0000-0002-2775-3681","position":4,"is_corresponding":false},{"id":1722000,"name":"Ulf Darsow","orcid":null,"position":5,"is_corresponding":false},{"id":1252,"name":"Tilo Biedermann","orcid":"0000-0002-5352-5105","position":6,"is_corresponding":false},{"id":1251,"name":"Bernadette Eberlein","orcid":"0000-0003-4509-6491","position":7,"is_corresponding":false},{"id":1721998,"name":"Paul Schmidle","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Basophil Activation Test in Double-Sensitized Patients With Hymenoptera Venom Allergy: Additional Benefit of Component-Resolved Diagnostics","abstract":"<h4>Background</h4>In Hymenoptera venom allergy serologically double-sensitized patients, it is often difficult to identify the culprit insect for venom immunotherapy (VIT).<h4>Objectives</h4>To evaluate if basophil activation tests (BATs) performed not only with venom extracts but additionally with single component-resolved diagnostics could differentiate between sensitized and allergic individuals and how the test results influenced the physicians' decision regarding VIT.<h4>Methods</h4>BATs were performed with bee and wasp venom extracts and with single components (Api m 1, Api m 10, Ves v 1, and Ves v 5) in 31 serologically double-sensitized patients.<h4>Results</h4>In 28 finally included individuals, 9 BATs were positive and 4 negative for both venoms. Fourteen of 28 BATs showed positive results for wasp venom alone. Two of 10 BATs positive for bee venom were only positive to Api m 1 and 1 of 28 BATs only to Api m 10, but not for whole bee venom extract. Five of 23 BATs positive for wasp venom were only positive for Ves v 5 but negative for wasp venom extract and Ves v 1. Finally, VIT with both insect venoms was recommended in 4 of 28 individuals, with wasp venom alone in 21 of 28 patients and with bee venom alone in 1 of 28. In 2 cases no VIT was recommended.<h4>Conclusions</h4>BATs with Ves v 5, followed by Api m 1 and Api m 10, were helpful for the decision for VIT with the clinically relevant insect in 8 of 28 (28.6%) patients. A BAT with components should therefore be additionally carried out in cases with equivocal results.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37302791","pmcid":null,"openalex_id":"https://openalex.org/W4380200495","authors":[],"funders":[],"total_grants":0,"fwci":2.0343,"citation_percentile":0.87234043,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":6},{"year":2025,"count":7}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S2213219823006505?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213219823006505?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jaip.2023.06.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37302791","host_type":"repository"},{"url":"https://mediatum.ub.tum.de/1743602","host_type":"repository"},{"url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=67831","host_type":"repository"}],"fields_of_study":["Food Allergy and Anaphylaxis Research","Healthcare and Venom Research","Mast cells and histamine","Humans","Animals","Hymenoptera","Arthropod Venoms","Allergens","Wasp Venoms","Basophil Degranulation Test","Venom Hypersensitivity","Immunoglobulin E","Hypersensitivity","Bee Venoms","Insect Bites and Stings"],"mesh_terms":["Venom Hypersensitivity","Allergens","Animals","Arthropod Venoms","Bee Venoms","Humans","Hymenoptera","Hypersensitivity","Immunoglobulin E","Insect Bites and Stings","Wasp Venoms","Basophil Degranulation Test"],"keywords":["Venom","Basophil activation","Allergy","Bee venom","Medicine","Immunology","Hymenoptera","Anaphylaxis","Biology","Allergen","Basophil","Zoology","Immunoglobulin E","Antibody","Ecology","Basophil Activation Test","Venom Immunotherapy","Hymenoptera Venom Allergy","Molecular Allergens","Ves V 5","Api M 1","Api M 10","Ves V 1"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T07:22:45.178380Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}