{"doi":"10.1016/j.jaip.2022.02.032","title":"Risk Factors for Persistent Chronic Cough During Consecutive Years: A Retrospective Database Analysis","abstract":"BACKGROUND: The identification of patients at high risk for diseases provides clinicians essential information to better manage such patients. Persistent chronic cough (PCC) is a condition with high clinical burden and limited knowledge of the risk factors that drive the persistent symptoms. OBJECTIVE: To understand the risk factors of PCC in patients with CC diagnosed by specialists. METHODS: In this retrospective study, adults aged 18 to 85 years diagnosed with CC by a pulmonologist, allergist, otolaryngologist, or gastroenterologist in the period 2011 to 2016 were identified. PCC was defined by another CC code or at least 2 cough events at least 8 weeks but no more than 4 months apart in each of the 2 consecutive years beginning 1 year after the original CC diagnosis. Unadjusted and adjusted risk ratios with 95% CI for patient characteristics at baseline in relationship to PCC were estimated by Poisson regression models with robust error variance. RESULTS: Of the adults with CC, 3270 (27.4%) had PCC and 5302 (44.5%) did not have CC during follow-up; 3341 (28.1%) had CC in only 1 follow-up year and were excluded from the analysis. Compared with patients without PCC, patients with PCC were noted to have significantly increased adjusted risk ratios for the following baseline features: (1) demographic characteristics (elderly, females, and less educated); (2) comorbidities (chronic obstructive pulmonary disease, chronic sinusitis, bronchiectasis, pulmonary fibrosis, hypertension, depression, and cough complications); (3) medication dispensed (inhaled corticosteroids/long-acting beta-agonists, leukotriene modifiers, nasal corticosteroids, nasal short-acting muscarinic antagonists, proton pump inhibitors, antitussives with narcotics, and neuromodulators); and (4) specialist care, particularly with pulmonologists. CONCLUSIONS: Knowledge of the independent risk factors associated with PCC should aid clinicians in identifying such patients and improve their management.","journal":"The Journal of Allergy and Clinical Immunology In Practice","year":2022,"id":280677,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6827,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":253332,"name":"Michael Schatz","orcid":null,"position":1,"is_corresponding":false},{"id":955150,"name":"Yichen Zhou","orcid":"0000-0002-0596-2087","position":2,"is_corresponding":false},{"id":909058,"name":"Fagen Xie","orcid":"0000-0002-1565-0490","position":3,"is_corresponding":false},{"id":307393,"name":"Vishal Bali","orcid":"0009-0000-0058-8180","position":4,"is_corresponding":false},{"id":955536,"name":"Jonathan Schelfhout","orcid":null,"position":5,"is_corresponding":false},{"id":731456,"name":"Amar K. Das","orcid":"0000-0003-3556-0844","position":6,"is_corresponding":false},{"id":955151,"name":"Julie Stern","orcid":"0000-0002-0888-0810","position":7,"is_corresponding":false},{"id":307394,"name":"Wansu Chen","orcid":"0000-0002-3486-7468","position":8,"is_corresponding":false},{"id":252197,"name":"Robert S. Zeiger","orcid":"0000-0001-5788-5063","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:29:03.247347Z","pmid":"35272071","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}