{"doi":"10.1016/j.jaip.2021.10.023","title":"The Majority of Children Sensitized Before School-Age Develop Allergic Disease Before Adulthood: A Longitudinal Population-Based Study","abstract":"BACKGROUND: Allergic sensitization increases the risk of asthma and allergic rhinitis, but the impact of age at onset of sensitization is less studied. OBJECTIVE: To examine the cumulative incidence of asthma and rhinitis up to age 19 years in relation to age at onset of sensitization to airborne allergens. METHOD: All children in grade 1 and 2 (median age, 8 years) in 2 municipalities in Northern Sweden were invited to undergo skin prick tests and answer a questionnaire about allergic diseases, and 88% participated. At ages 12 and 19 years, the protocol was repeated, and 1510 individuals participated in all 3 examinations. Specific IgE data were collected in a random sample at age 19 years (n = 770). Onset of sensitization was defined: 8 years or less, 8 to 12 years, 12 to 19 years, and never sensitized. Adjusted Poisson regression was used to calculate risk ratios (RRs). RESULTS: At 19 years, those sensitized at 8 years of age or earlier had the highest risk of asthma (RR, 4.68; 95% CI, 3.15-6.97) and rhinitis (RR, 22.3; 95% CI, 13.3-37.6), and 84% had developed either asthma or rhinitis. The combination of sensitization at age 8 years or earlier and family history of allergic diseases rendered high risks for asthma (RR, 10.6; 95% CI, 6.71-16.7) and rhinitis (RR, 36.3; 95% CI, 18.9-69.7). Individuals sensitized at age 8 years or earlier showed significantly highest level of sensitization, as judged by number of positive skin test results and titers of specific IgE. CONCLUSIONS: Most individuals with sensitization at age 8 years or earlier developed asthma or rhinitis before young adulthood. The high level of sensitization in those sensitized early contributes to the high incidence of allergic airway conditions.","journal":"The Journal of Allergy and Clinical Immunology In Practice","year":2021,"id":169619,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6729,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":700699,"name":"Linnéa Hedman","orcid":"0000-0002-1630-3167","position":1,"is_corresponding":false},{"id":457353,"name":"Matthew S. Perzanowski","orcid":"0000-0003-1300-0985","position":2,"is_corresponding":false},{"id":700700,"name":"Anders Bjerg","orcid":"0000-0001-5723-6215","position":3,"is_corresponding":false},{"id":701393,"name":"Anna Winberg","orcid":null,"position":4,"is_corresponding":false},{"id":700701,"name":"Martin Andersson","orcid":"0000-0001-7222-6402","position":5,"is_corresponding":false},{"id":605895,"name":"Bo Lundbäck","orcid":"0000-0002-7196-3651","position":6,"is_corresponding":false},{"id":334951,"name":"Thomas A.E. Platts‐Mills","orcid":"0000-0002-1263-329X","position":7,"is_corresponding":false},{"id":478628,"name":"Eva Rönmark","orcid":"0000-0002-2358-8754","position":8,"is_corresponding":false},{"id":700698,"name":"Joakim Bunne","orcid":"0000-0002-8174-6634","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T23:46:15.560174Z","pmid":"34695595","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}