{"doi":"10.1016/j.jaip.2019.04.036","title":"Novel Strategy for the Prevention of Recurrent Hypersensitivity Reactions to Radiocontrast Media Based on Skin Testing","abstract":null,"journal":"The Journal of Allergy and Clinical Immunology: In Practice","year":2019,"id":663756,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1733050,"name":"Ji-Hyang Lee","orcid":null,"position":1,"is_corresponding":false},{"id":1641243,"name":"So-Young Park","orcid":null,"position":2,"is_corresponding":false},{"id":1733051,"name":"Bomi Seo","orcid":null,"position":3,"is_corresponding":false},{"id":1733052,"name":"Ha-Kyeong Won","orcid":null,"position":4,"is_corresponding":false},{"id":1733053,"name":"Yewon Kang","orcid":null,"position":5,"is_corresponding":false},{"id":1677677,"name":"Jin An","orcid":null,"position":6,"is_corresponding":false},{"id":1733054,"name":"Hyouk-Soo Kwon","orcid":null,"position":7,"is_corresponding":false},{"id":1733055,"name":"Woo-Jung Song","orcid":null,"position":8,"is_corresponding":false},{"id":1733056,"name":"You Sook Cho","orcid":null,"position":9,"is_corresponding":false},{"id":1733057,"name":"Hee-Bom Moon","orcid":null,"position":10,"is_corresponding":false},{"id":1733058,"name":"Tae-Bum Kim","orcid":null,"position":11,"is_corresponding":false},{"id":1733049,"name":"Oh Young Kwon","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Novel Strategy for the Prevention of Recurrent Hypersensitivity Reactions to Radiocontrast Media Based on Skin Testing","abstract":"<h4>Background</h4>Hypersensitivity reactions to iodinated contrast media (ICM) is a persistent clinical issue with increased use of computed tomography. With the evidence indicating underlying allergic mechanisms, there have been studies regarding the skin tests using ICM.<h4>Objective</h4>This study aimed to evaluate the intradermal skin test (IDT) as a tool for preventing recurrent hypersensitivity reactions to ICM in patients with prior reactions to a known culprit agent.<h4>Methods</h4>Sixty-nine patients who had experienced immediate hypersensitivity reactions to ICM were included in the study. All patients underwent IDT with 7 different ICMs, including the causative ICM. We analyzed clinical data from 38 patients who were reexposed to ICMs, grouped by the IDT results to their original culprit ICM.<h4>Results</h4>Thirty-eight patients showed positive IDT results to the culprit ICM (CULPRIT+), whereas 31 patients showed negative results (CULPRIT-). Sixteen patients from the CULPRIT+ group and 22 from the CULPRIT- group were subsequently exposed to an ICM. In the CULPRIT+ group, 4 of the 5 patients who were subsequently exposed to an IDT-positive ICM reexperienced hypersensitivity reactions. When patients were exposed to IDT-negative ICM as an alternative, hypersensitivity reactions were not observed. In the CULPRIT- group, IDT-positive ICMs did not provoke hypersensitivity reactions whereas 2 patients using IDT-negative ICMs experienced hypersensitivity reactions.<h4>Conclusions</h4>When the IDT results are positive for the culprit ICM, additional IDTs with other ICMs are needed to select a safe alternative. If the IDT results are negative against the culprit ICM, further IDTs might not play a role in selecting a safe alternative.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31078762","pmcid":null,"openalex_id":"https://openalex.org/W2911429319","authors":[],"funders":[{"funder_name":"Ministry of Health and Welfare","grant_id":"","title":null}],"total_grants":1,"fwci":3.9249,"citation_percentile":0.94286723,"influential_citations":0,"citation_trend":[{"year":2019,"count":4},{"year":2020,"count":12},{"year":2021,"count":5},{"year":2022,"count":7},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S2213219819304404?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213219819304404?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jaip.2019.04.036","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31078762","host_type":"repository"}],"fields_of_study":["Acute Kidney Injury Research","Lanthanide and Transition Metal Complexes","Ultrasound and Hyperthermia Applications"],"mesh_terms":["Adult","Aged","Contrast Media","Drug Hypersensitivity","Female","Humans","Hypersensitivity, Immediate","Male","Middle Aged","Recurrence","Skin Tests","Iodine Compounds"],"keywords":["Medicine","Patch testing","Dermatology","Skin reaction","Delayed hypersensitivity","Allergy","Contact dermatitis","Immunology","Antigen","skin tests","Premedication","Intradermal Skin Test","Hypersensitivity Reaction","Iodinated Contrast Media"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T23:21:51.708795Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}