{"doi":"10.1016/j.jad.2024.12.056","title":"Rumination induction task in fMRI: Effects of rumination focused cognitive behavioral therapy and stability in youth","abstract":"BACKGROUND: Rumination is implicated in the onset and maintenance of major depressive disorder (MDD). Rumination-Focused Cognitive Behavioral Therapy (RF-CBT) effectively targets rumination and may change resting-state brain connectivity and change in activation during a rumination induction task (RIT) post-intervention predicts depressive symptoms two years later. We examined brain activation changes during an RIT in adolescents with remitted MDD following RF-CBT and evaluated RIT reliability (or stability) during treatment as usual (TAU). METHOD: Fifty-five adolescents ages 14-17 completed an RIT at baseline, were randomized to 10-14 sessions of RF-CBT (n = 30) or treatment as usual (n = 25) and completed an RIT at post-treatment or equivalent time delay. The RIT includes recalling negative memories (Rumination Instruction), dwelling on their meaning/consequences (Rumination Prompt), and imagining unrelated scenes and objects (Distraction). We assessed activation change in the RF-CBT group using paired-samples t-tests. We assessed reliability (or stability) via intraclass correlation coefficients (ICCs) of five rumination-related ROIs for TAU and RF-CBT separately across task blocks. RESULTS: Following treatment, participants receiving RF-CBT demonstrated increased activation of left precuneus during Rumination Instruction and of left angular and superior temporal gyri during Rumination Prompt blocks (p < .01). From baseline to post-treatment, across most ROIs and task blocks, the RF-CBT group demonstrated poor stability (M = 0.21, range = -0.19-0.69), while the TAU group demonstrated fair-to-excellent stability (M = 0.52, range = 0.27-0.86). CONCLUSION: RF-CBT changes activation of rumination-related circuitry during state-induced rumination, offering exciting avenues for future interventions. The RIT has fair-to-excellent stability among individuals not explicitly treated for rumination, and as expected, RIT stability is disrupted by RF-CBT.","journal":"Journal of Affective Disorders","year":2024,"id":470172,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.947,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1304664,"name":"A. M. Jacobsen","orcid":null,"position":1,"is_corresponding":false},{"id":1047643,"name":"Brian Farstead","orcid":"0000-0002-9919-0769","position":2,"is_corresponding":false},{"id":1304665,"name":"Raina H. Miller","orcid":null,"position":3,"is_corresponding":false},{"id":1047646,"name":"Rachel H. Jacobs","orcid":"0000-0003-4951-2704","position":4,"is_corresponding":false},{"id":721682,"name":"Leah Thomas","orcid":"0000-0001-8671-954X","position":5,"is_corresponding":false},{"id":975652,"name":"Katie L. Bessette","orcid":"0000-0002-7423-4884","position":6,"is_corresponding":false},{"id":1047644,"name":"Myah Pazdera","orcid":"0000-0003-1610-4157","position":7,"is_corresponding":false},{"id":267630,"name":"Sheila E. Crowell","orcid":"0000-0003-1296-6614","position":8,"is_corresponding":false},{"id":858786,"name":"Erin A. Kaufman","orcid":"0000-0002-7636-6602","position":9,"is_corresponding":false},{"id":1029550,"name":"Daniel Feldman","orcid":"0000-0003-1644-7504","position":10,"is_corresponding":false},{"id":1047641,"name":"Henrietta Roberts","orcid":"0000-0002-0831-2645","position":11,"is_corresponding":false},{"id":1047645,"name":"Robert C. Welsh","orcid":"0000-0002-8701-694X","position":12,"is_corresponding":false},{"id":1020846,"name":"Edward Watkins","orcid":"0000-0002-2432-5577","position":13,"is_corresponding":false},{"id":392549,"name":"Scott A. Langenecker","orcid":"0000-0002-7932-5494","position":14,"is_corresponding":false},{"id":477455,"name":"Mindy Westlund Schreiner","orcid":"0000-0002-2780-3327","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:05:36.656771Z","pmid":"39701467","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}