{"doi":"10.1016/j.jad.2024.03.023","title":"Reduced coupling between global signal and cerebrospinal fluid inflow in patients with depressive disorder: A resting state functional MRI study","abstract":null,"journal":"Journal of Affective Disorders","year":2024,"id":639029,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":331534,"name":"Bo Peng","orcid":"0000-0002-1915-0549","position":1,"is_corresponding":false},{"id":79034,"name":"Shengli Chen","orcid":"0009-0006-4915-0853","position":2,"is_corresponding":false},{"id":1545245,"name":"Qunjun Liang","orcid":null,"position":3,"is_corresponding":false},{"id":1612779,"name":"Yingli Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":1660062,"name":"Shiwei Lin","orcid":null,"position":5,"is_corresponding":false},{"id":1660065,"name":"Ziyun Xu","orcid":null,"position":6,"is_corresponding":false},{"id":1162657,"name":"Jiayun Zhang","orcid":"0000-0002-3562-5794","position":7,"is_corresponding":false},{"id":1660066,"name":"Gangqiang Hou","orcid":null,"position":8,"is_corresponding":false},{"id":1660067,"name":"Yingwei Qiu","orcid":null,"position":9,"is_corresponding":false},{"id":1227170,"name":"Yanyu Zhang","orcid":"0000-0001-7284-8295","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Reduced coupling between global signal and cerebrospinal fluid inflow in patients with depressive disorder: A resting state functional MRI study","abstract":"<h4>Background</h4>Depressed patients often suffer from sleep disturbance, which has been recognized to be responsible for glymphatic dysfunction. The purpose of this study was to investigate the coupling strength of global blood‑oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow dynamics, which is a biomarker for glymphatic function, in depressed patients and to explore its potential relationship with sleep disturbance by using resting-state functional MRI.<h4>Methods</h4>A total of 138 depressed patients (112 females, age: 34.70 ± 13.11 years) and 84 healthy controls (29 females, age: 36.6 ± 11.75 years) participated in this study. The gBOLD-CSF coupling strength was calculated to evaluate glymphatic function. Sleep disturbance was evaluated using the insomnia items (item 4 for insomnia-early, item 5 for insomnia-middle, and item 6 for insomnia-late) of The 17-item Hamilton Depression Rating Scale for depressed patients, which was correlated with the gBOLD-CSF coupling strength.<h4>Results</h4>The depressed patients exhibited weaker gBOLD-CSF coupling relative to healthy controls (p = 0.022), possibly due to impairment of the glymphatic system. Moreover, the gBOLD-CSF coupling strength correlated with insomnia-middle (r = 0.097, p = 0.008) in depressed patients. Limitations This study is a cross-sectional study.<h4>Conclusion</h4>Our findings shed light on the pathophysiology of depression, indicating that cerebral waste clearance system deficits are correlated with poor sleep quality in depressed patients.","is_dataset_classified":null,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38484877","pmcid":null,"openalex_id":"https://openalex.org/W4392710982","authors":[],"funders":[{"funder_name":"Ministry of Science and Technology of the People&apos;s Republic of China","grant_id":"","title":null}],"total_grants":1,"fwci":7.3192,"citation_percentile":0.98158756,"influential_citations":0,"citation_trend":[{"year":2025,"count":19},{"year":2026,"count":20}],"oa_status":"closed","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0165032724004385?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0165032724004385?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jad.2024.03.023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38484877","host_type":"repository"}],"fields_of_study":["Cerebrospinal fluid and hydrocephalus","Traumatic Brain Injury and Neurovascular Disturbances","Functional Brain Connectivity Studies","Female","Humans","Young Adult","Adult","Middle Aged","Sleep Initiation and Maintenance Disorders","Cross-Sectional Studies","Glymphatic System","Sleep Wake Disorders","Magnetic Resonance Imaging","Depressive Disorder"],"mesh_terms":["Glymphatic System","Adult","Cross-Sectional Studies","Depressive Disorder","Female","Humans","Sleep Initiation and Maintenance Disorders","Magnetic Resonance Imaging","Middle Aged","Sleep Wake Disorders","Young Adult"],"keywords":["Glymphatic system","Cerebrospinal fluid","Insomnia","Internal medicine","Depression (economics)","Psychology","Sleep disorder","Cardiology","Pathophysiology","Case-control study","Medicine","Psychiatry","Depression","Sleep Disturbance","Blood‑oxygen Level Dependent"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T22:16:19.309851Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}