{"doi":"10.1016/j.jad.2022.11.051","title":"Factors associated with anxiety disorder comorbidity","abstract":"BACKGROUND: Anxiety and depressive disorders often co-occur and the order of their emergence may be associated with different clinical outcomes. However, minimal research has been conducted on anxiety-anxiety comorbidity. This study examined factors associated with anxiety comorbidity and anxiety-MDD temporal sequence. METHODS: Online, self-report data were collected from the UK-based GLAD and COPING NBR cohorts (N = 38,775). Logistic regression analyses compared differences in sociodemographic, trauma, and clinical factors between single anxiety, anxiety-anxiety comorbidity, anxiety-MDD (major depressive disorder) comorbidity, and MDD-only. Additionally, anxiety-first and MDD-first anxiety-MDD were compared. Differences in familial risk were assessed in those participants with self-reported family history or genotype data. RESULTS: Anxiety-anxiety and anxiety-MDD had higher rates of self-reported anxiety or depressive disorder diagnoses, younger age of onset, and higher recurrence than single anxiety. Anxiety-MDD displayed greater clinical severity/complexity than MDD only. Anxiety-anxiety had more severe current anxiety symptoms, less severe current depressive symptoms, and reduced likelihood of self-reporting an anxiety/depressive disorder diagnosis than anxiety-MDD. Anxiety-first anxiety-MDD had a younger age of onset, more severe anxiety symptoms, and less likelihood of self-reporting a diagnosis than MDD-first. Minimal differences in familial risk were found. LIMITATIONS: Self-report, retrospective measures may introduce recall bias. The familial risk analyses were likely underpowered. CONCLUSIONS: Anxiety-anxiety comorbidity displayed a similarly severe and complex profile of symptoms as anxiety-MDD but distinct features. For anxiety-MDD, first-onset anxiety had an earlier age of onset and greater severity than MDD-first. Anxiety disorders and comorbidity warrant further investigation and attention in research and practice.","journal":"Journal of Affective Disorders","year":2022,"id":245341,"datarank":0.8150920622376968,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.3383839876855049,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.3383839876855049,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":20,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8858,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":879891,"name":"Kiran Glen","orcid":"0000-0002-2831-3266","position":1,"is_corresponding":false},{"id":654521,"name":"Jessica Mundy","orcid":null,"position":2,"is_corresponding":false},{"id":653851,"name":"Abigail ter Kuile","orcid":"0000-0002-7869-3754","position":3,"is_corresponding":false},{"id":653837,"name":"Brett N. 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Hirsch","orcid":"0000-0003-3579-2418","position":9,"is_corresponding":false},{"id":264610,"name":"Matthew Hotopf","orcid":"0000-0002-3980-4466","position":10,"is_corresponding":false},{"id":304138,"name":"Christopher Hübel","orcid":"0000-0002-1267-8287","position":11,"is_corresponding":false},{"id":254654,"name":"Ian Jones","orcid":"0000-0001-5821-5889","position":12,"is_corresponding":false},{"id":304169,"name":"Gursharan Kalsi","orcid":"0000-0002-5156-7176","position":13,"is_corresponding":false},{"id":494292,"name":"Georgina Krebs","orcid":"0000-0002-5353-5645","position":14,"is_corresponding":false},{"id":217,"name":"Andrew M. McIntosh","orcid":"0000-0002-0198-4588","position":15,"is_corresponding":false},{"id":857987,"name":"Geneviève Morneau‐Vaillancourt","orcid":"0000-0002-5322-6252","position":16,"is_corresponding":false},{"id":653847,"name":"Alicia J. Peel","orcid":"0000-0002-6144-5412","position":17,"is_corresponding":false},{"id":475710,"name":"Kirstin L. 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