{"doi":"10.1016/j.jad.2021.05.090","title":"Does pre-treatment functioning influence response to intravenous ketamine in adults with treatment-resistant depression?","abstract":null,"journal":"Journal of Affective Disorders","year":2021,"id":605818,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1554907,"name":"Orly Lipsitz","orcid":null,"position":1,"is_corresponding":false},{"id":1554908,"name":"Leanna M W Lui","orcid":null,"position":2,"is_corresponding":false},{"id":1554910,"name":"Nelson B Rodrigues","orcid":null,"position":3,"is_corresponding":false},{"id":324321,"name":"Yena Lee","orcid":"0000-0003-0629-9456","position":4,"is_corresponding":false},{"id":54890,"name":"Roger C. Ho","orcid":"0000-0001-9629-4493","position":5,"is_corresponding":false},{"id":324320,"name":"Mehala Subramaniapillai","orcid":"0000-0002-6917-3984","position":6,"is_corresponding":false},{"id":1554914,"name":"Hartej Gill","orcid":"0000-0002-3568-8816","position":7,"is_corresponding":false},{"id":1554916,"name":"Danielle S Cha","orcid":null,"position":8,"is_corresponding":false},{"id":1554918,"name":"Kangguang Lin","orcid":null,"position":9,"is_corresponding":false},{"id":1554920,"name":"Kayla M Teopiz","orcid":null,"position":10,"is_corresponding":false},{"id":324322,"name":"Flora Nasri","orcid":"0000-0002-0627-3558","position":11,"is_corresponding":false},{"id":1554923,"name":"Rodrigo B Mansur","orcid":null,"position":12,"is_corresponding":false},{"id":615226,"name":"Kevin Kratiuk","orcid":"0000-0002-6204-2148","position":13,"is_corresponding":false},{"id":1554926,"name":"Joshua D Rosenblat","orcid":null,"position":14,"is_corresponding":false},{"id":324331,"name":"Roger S. McIntyre","orcid":"0000-0003-4733-2523","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Does pre-treatment functioning influence response to intravenous ketamine in adults with treatment-resistant depression?","abstract":"<h4>Background</h4>The efficacy of monoamine-based antidepressants in adults with major depressive disorder (MDD) is attenuated in persons with greater pre-treatment functional impairment. Herein, we investigated whether pre-treatment functioning in outpatients with treatment-resistant depression (TRD) moderates response to intravenous (IV) ketamine.<h4>Methods</h4>Adults (N= 326; M<sub>age</sub> = 45) with DSM-5-defined MDD or bipolar disorder and TRD received repeat-dose IV ketamine at a community-based clinic. Function was evaluated with the Sheehan Disability Scale (SDS), using total scores as well as scores on the subdomains of workplace/school, social life, and family life/home responsibilities. The primary dependent measure was change in depressive symptoms from pre-treatment to post-infusion 4, as measured by the Quick Inventory for Depressive Symptomatology-Self Report-16.<h4>Results</h4>Total functional disability, as well as the subdomains of social life and family life/home responsibilities, significantly moderated response to IV ketamine (p = .003; p = .008; p = .008). Follow-up simple slopes analyses indicated a significant improvement in depressive symptoms across the functional domain spectrum (ps < .001). Above average functional disability (i.e., 1 SD > mean functional impairment within the sample) was associated with a greater change in depressive symptoms. Workplace function did not significantly moderate response to IV ketamine (p = .307), suggesting that individuals with significantly impaired workplace functioning may expect a similar response to ketamine as those with less workplace impairment.<h4>Conclusions</h4>Symptomatic benefit with IV ketamine was observed in patients with TRD and significant pre-treatment functional impairment. The foregoing result has implications for mechanism of action, cost-effectiveness, and patient selection in adults with TRD receiving IV ketamine.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34161889","pmcid":null,"openalex_id":"https://openalex.org/W3173182937","authors":[],"funders":[],"total_grants":0,"fwci":0.7549,"citation_percentile":0.70326513,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0165032721005358?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0165032721005358?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jad.2021.05.090","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34161889","host_type":"repository"},{"url":"http://repository.hkust.edu.hk/ir/Record/1783.1-142743","host_type":"repository"}],"fields_of_study":["Treatment of Major Depression","Bipolar Disorder and Treatment","Tryptophan and brain disorders"],"mesh_terms":["Adult","Bipolar Disorder","Depression","Depressive Disorder, Major","Major Depressive Disorder","Humans","Infusions, Intravenous","Ketamine","Middle Aged","Depressive Disorder, Treatment-Resistant"],"keywords":["Ketamine","Treatment-resistant depression","Major depressive disorder","Depression (economics)","Psychology","Functional impairment","Depressive symptoms","Late life depression","Psychiatry","Clinical psychology","Medicine","Cognition","Function","Bipolar disorder","Workplace","Crtce"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:18:13.820918Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}