{"doi":"10.1016/j.jad.2020.10.027","title":"Rare Functional Variants Associated with Antidepressant Remission in Mexican-Americans","abstract":"INTRODUCTION: Rare genetic functional variants can contribute to 30-40% of functional variability in genes relevant to drug action. Therefore, we investigated the role of rare functional variants in antidepressant response. METHOD: Mexican-American individuals meeting the Diagnostic and Statistical Manual-IV criteria for major depressive disorder (MDD) participated in a prospective randomized, double-blind study with desipramine or fluoxetine. The rare variant analysis was performed using whole-exome genotyping data. Network and pathway analyses were carried out with the list of significant genes. RESULTS: The Kernel-Based Adaptive Cluster method identified functional rare variants in 35 genes significantly associated with treatment remission (False discovery rate, FDR <0.01). Pathway analysis of these genes supports the involvement of the following gene ontology processes: olfactory/sensory transduction, regulation of response to cytokine stimulus, and meiotic cell cycleprocess. LIMITATIONS: Our study did not have a placebo arm. We were not able to use antidepressant blood level as a covariate. Our study is based on a small sample size of only 65 Mexican-American individuals. Further studies using larger cohorts are warranted. CONCLUSION: Our data identified several rare functional variants in antidepressant drug response in MDD patients. These have the potential to serve as genetic markers for predicting drug response. TRIAL REGISTRATION: ClinicalTrials.gov NCT00265291.","journal":"Journal of Affective Disorders","year":2020,"id":85280,"datarank":0.474339576946295,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.16242334569431963,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.16242334569431963,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":6,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT00265291"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":349954,"name":"Mauricio Arcos‐Burgos","orcid":"0000-0002-8529-0574","position":1,"is_corresponding":false},{"id":436267,"name":"Sha Liu","orcid":"0000-0002-6710-8126","position":2,"is_corresponding":false},{"id":437064,"name":"Alice W. Licinio","orcid":null,"position":3,"is_corresponding":false},{"id":436268,"name":"Chenglong Yu","orcid":"0000-0002-0546-2779","position":4,"is_corresponding":false},{"id":436269,"name":"E Chin","orcid":"0000-0002-0933-7166","position":5,"is_corresponding":false},{"id":196084,"name":"Wei-Dong Yao","orcid":null,"position":6,"is_corresponding":false},{"id":295399,"name":"Xin‐Yun Lu","orcid":"0000-0002-9103-4542","position":7,"is_corresponding":false},{"id":17043,"name":"Stefan R. Bornstein","orcid":"0000-0002-5211-2536","position":8,"is_corresponding":false},{"id":303750,"name":"Júlio Licinio","orcid":"0000-0001-6905-5884","position":9,"is_corresponding":false},{"id":436266,"name":"Ma‐Li Wong","orcid":"0000-0003-1512-3073","position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-18T21:56:02.794896Z","pmid":"33128939","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}