{"doi":"10.1016/j.jacl.2025.12.008","title":"Gender differences in lipid management, LDL-C goal attainment, and prescribing practices","abstract":null,"journal":"Journal of Clinical Lipidology","year":2026,"id":651969,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":422652,"name":"Caroline Ong","orcid":"0000-0003-4432-5926","position":1,"is_corresponding":false},{"id":1262030,"name":"Xueqi Huang","orcid":"0009-0003-5664-3451","position":2,"is_corresponding":false},{"id":1700553,"name":"Spencer Weintraub","orcid":"0009-0009-1254-9344","position":3,"is_corresponding":false},{"id":1700554,"name":"Nisha Parikh","orcid":null,"position":4,"is_corresponding":false},{"id":1700555,"name":"Stacey Rosen","orcid":null,"position":5,"is_corresponding":false},{"id":632496,"name":"Eugenia Gianos","orcid":"0000-0001-7720-7470","position":6,"is_corresponding":false},{"id":810166,"name":"Natasha Vartak","orcid":"0009-0001-9155-7992","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gender differences in lipid management, LDL-C goal attainment, and prescribing practices","abstract":"<h4>Background</h4>A large evidence base supports lipid lowering to reduce atherosclerotic cardiovascular disease (ASCVD) morbidity and mortality. Despite guideline-recommended lipid-lowering therapies (LLT), gender-based disparities in lipid management persist, with women less likely to be treated aggressively and achieve optimal low-density lipoprotein cholesterol (LDL-C) levels.<h4>Objective</h4>We aimed to investigate whether provider gender impacted lipid treatment gaps.<h4>Methods</h4>We conducted a retrospective chart review of 364,021 adults within a large health system who underwent lipid testing between 2022 and 2023. Demographic, clinical, and prescribing data were abstracted from electronic health records. Optimal LDL-C was defined based on ASCVD risk.<h4>Results</h4>Women had higher mean LDL-C (108 vs 102 mg/dL, P < .0001) and were less likely to achieve an LDL-C of <100 mg/dL (41% vs 47%, P < .0001) compared to men. Among those with ASCVD, only 31% of women vs 47% of men achieved an LDL-C <70 mg/dL (P < .0001). Women were less likely to be prescribed statins (26% vs 33%, P < .0001) in the overall population and high-intensity statins (23% vs 31%, P < .0001) in the ASCVD population than men. No prescribing difference was noted between male and female providers across specialties.<h4>Conclusion</h4>Women with or at risk for ASCVD experience lower rates of LLT prescription and LDL-C goal attainment compared to men. These disparities underscore the need for targeted interventions to improve LDL-C goal attainment in women.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41494938","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Northwell Health","grant_id":"","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1933287425005380?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1933287425005380?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Hydroxymethylglutaryl-CoA Reductase Inhibitors","Retrospective Studies","Sex Factors","Sex Characteristics","Adult","Aged","Middle Aged","Female","Male","Atherosclerosis","Cholesterol, LDL","Practice Patterns, Physicians'"],"keywords":["Lipids","Prevention","Cardiovascular disease","statins","Women’s Health","Gender Disparities","Provider Gender"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T11:24:44.942987Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}