{"doi":"10.1016/j.jacl.2020.04.009","title":"The association between triglycerides and incident cardiovascular disease: What is “optimal”?","abstract":"BACKGROUND: Elevated triglycerides (TGs) are associated with increased risk of cardiovascular disease (CVD), but the best way to both measure TGs and assess TG-related risk remains unknown. OBJECTIVE: The objective of the study was to evaluate the association between TGs and CVD and determine whether the average of a series of TG measurements is more predictive of CVD risk than a single TG measurement. METHODS: We examined 15,792 study participants, aged 40-65 years, free of CVD from the Atherosclerosis Risk in Communities and Framingham Offspring studies, using fasting TG measurements across multiple examinations over time. With up to 10 years of follow-up, we assessed time-to-first CVD event, as well as a composite of myocardial infarction, stroke, or cardiovascular death. RESULTS: Compared with a single TG measurement, average TGs over time had greater discrimination for CVD risk (C-statistic, 0.60 vs 0.57). Risk for CVD increased as average TGs rose until an inflection point of ~100 mg/dL in men and ~200 mg/dL in women, above which this risk association plateaued. The relationship between average TGs and CVD remained statistically significant in multivariable modeling adjusting for low-density lipoprotein cholesterol, and interactions were found by sex and high-density lipoprotein cholesterol level. CONCLUSIONS: The average of several TG readings provides incremental improvements for the prediction of CVD relative to a single TG measurement. Regardless of the method of measurement, higher TGs were associated with increased CVD risk, even at levels previously considered \"optimal\" (<150 mg/dL).","journal":"Journal of clinical lipidology","year":2020,"id":53289,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":119,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271438,"name":"Eric D. Peterson","orcid":"0000-0002-5415-4721","position":1,"is_corresponding":false},{"id":271439,"name":"Neha J. Pagidipati","orcid":"0000-0002-5004-8868","position":2,"is_corresponding":false},{"id":271440,"name":"Hillary Mulder","orcid":"0000-0003-4838-582X","position":3,"is_corresponding":false},{"id":272972,"name":"Daniel Wojdyla","orcid":null,"position":4,"is_corresponding":false},{"id":272973,"name":"Sephy Philip","orcid":null,"position":5,"is_corresponding":false},{"id":271441,"name":"Craig Granowitz","orcid":"0000-0003-1533-3679","position":6,"is_corresponding":false},{"id":45212,"name":"Ann Marie Návar","orcid":"0000-0002-6197-9860","position":7,"is_corresponding":false},{"id":271437,"name":"Tsion Aberra","orcid":"0000-0002-7370-8590","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T20:44:25.349797Z","pmid":"32571728","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}