{"doi":"10.1016/j.jacig.2025.100547","title":"Egg desensitization is achieved effectively and safely through a low maintenance dose protocol","abstract":null,"journal":"Journal of Allergy and Clinical Immunology: Global","year":2025,"id":621698,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553385,"name":"Nofar Kimchi","orcid":null,"position":1,"is_corresponding":false},{"id":525139,"name":"Wei Zhao","orcid":"0000-0001-9437-3198","position":2,"is_corresponding":false},{"id":1605581,"name":"Jana Abi-Rafeh","orcid":null,"position":3,"is_corresponding":false},{"id":1605582,"name":"Danbing Ke","orcid":null,"position":4,"is_corresponding":false},{"id":1605583,"name":"Duncan Lejtenyi","orcid":null,"position":5,"is_corresponding":false},{"id":1605584,"name":"Liane Beaudette","orcid":null,"position":6,"is_corresponding":false},{"id":1368403,"name":"Christine McCusker","orcid":"0000-0003-2150-9159","position":7,"is_corresponding":false},{"id":1605585,"name":"Bruce D. Mazer","orcid":null,"position":8,"is_corresponding":false},{"id":1362781,"name":"Moshe Ben-Shoshan","orcid":null,"position":9,"is_corresponding":false},{"id":1605580,"name":"Diana Toscano-Rivero","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Egg desensitization is achieved effectively and safely through a low maintenance dose protocol","abstract":"Background: Egg allergy is a common IgE-mediated food allergy in children. Oral immunotherapy (OIT) reduces allergic reactions via gradual allergen exposure. Although high maintenance doses (1-6 g egg protein) are often used, they carry higher risks of adverse reactions. Evidence on the safety and effectiveness of lower-dose egg OIT (E-OIT) remains limited. Objective: We sought to determine whether a low dose of 300 mg E-OIT is safe and effective for desensitization. Methods: Twenty-two participants were recruited from the Montreal Children's Hospital; 20 were randomized to an immediate-treatment group or an observation group (egg avoidance for 1 year before OIT). Cumulative tolerated dose (CTD), Gal d 1- and Gal d 2-specific IgE (sIgE) and -specific IgG4 (sIgG4), and skin prick test responses were measured at baseline, postescalation, and maintenance. Adverse events were recorded throughout the study. Results: < .001), and sIgG4/sIgE ratios improved. No significant clinical or immunologic changes occurred during the observation period. Conclusions: Targeting a low maintenance dose of 300 mg E-OIT produces significant clinical and immunologic changes in individuals with egg allergy while maintaining low risk of adverse reactions.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40978165","pmcid":"PMC12446774","openalex_id":"https://openalex.org/W4412805777","authors":[],"funders":[{"funder_name":"McGill University Health Centre","grant_id":"","title":null},{"funder_name":"The Montreal Children&apos;s Hospital Foundation","grant_id":"","title":null}],"total_grants":2,"fwci":0.8054,"citation_percentile":0.70396866,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jacig.2025.100547","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jacig.2025.100547","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2772829325001481?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2772829325001481?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40978165","host_type":"repository"},{"url":"https://doaj.org/article/b95fd4a785034cbeabd1da0ceb68201f","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12446774","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12446774/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12446774","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12446774?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Food Allergy and Anaphylaxis Research","Allergic Rhinitis and Sensitization","Eosinophilic Esophagitis"],"mesh_terms":[],"keywords":["Desensitization (medicine)","Protocol (science)","Medicine","Computer science","Internal medicine","Low dose","Food allergy","Skin Prick Test","Allergic Reactions","Oral Food Challenge","Egg Allergy","Dbpcfc","Oral Immunotherapy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T15:38:58.844576Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}