{"doi":"10.1016/j.jacig.2025.100507","title":"Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population","abstract":"Background: Asthma exacerbations are episodes of symptom worsening requiring increased therapy, which affect patients across all asthma severities. Potential genetic associations with asthma exacerbations in an understudied population were investigated. Objective: We sought to perform a genome-wide association study on severe asthma exacerbations in an admixed adult population with varying asthma severities and to explore potential epigenetic roles. Methods: via PhenoScanner v2. Results: ). Conclusions: The CXADR is highlighted as a potential novel susceptibility locus for asthma exacerbations, possibly tied to viral respiratory infections. Further replication and validation are needed.","journal":"Journal of Allergy and Clinical Immunology Global","year":2025,"id":567362,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":659977,"name":"Álvaro A. Cruz","orcid":"0000-0002-7403-3871","position":1,"is_corresponding":false},{"id":690866,"name":"Helena Mariana Pitangueira Teixeira","orcid":"0000-0003-2811-9401","position":2,"is_corresponding":false},{"id":1471748,"name":"Hatilla dos S. Silva","orcid":null,"position":3,"is_corresponding":false},{"id":1206004,"name":"Mahmoud I. Abdel‐Aziz","orcid":"0000-0001-9263-7137","position":4,"is_corresponding":false},{"id":892741,"name":"Simone Hashimoto","orcid":"0000-0001-8995-3817","position":5,"is_corresponding":false},{"id":378571,"name":"Susanne J. H. Vijverberg","orcid":"0000-0002-4579-4081","position":6,"is_corresponding":false},{"id":482381,"name":"Esther Herrera‐Luis","orcid":"0000-0003-4150-5454","position":7,"is_corresponding":false},{"id":378580,"name":"Maria Pino‐Yanes","orcid":"0000-0003-0332-437X","position":8,"is_corresponding":false},{"id":24949,"name":"Esteban G. Burchard","orcid":"0000-0001-7475-2035","position":9,"is_corresponding":false},{"id":856267,"name":"Kian Fan Chung","orcid":"0000-0001-7101-1426","position":10,"is_corresponding":false},{"id":856273,"name":"Ratko Djukanović","orcid":"0000-0001-6039-5612","position":11,"is_corresponding":false},{"id":856268,"name":"Sven‐Erik Dahlén","orcid":"0000-0002-4993-4002","position":12,"is_corresponding":false},{"id":20867,"name":"Ian M. Adcock","orcid":"0000-0003-2101-8843","position":13,"is_corresponding":false},{"id":329732,"name":"Corey Cox","orcid":"0000-0001-9042-5982","position":14,"is_corresponding":false},{"id":11285,"name":"Tonya M. Brunetti","orcid":"0000-0002-2228-2198","position":15,"is_corresponding":false},{"id":398697,"name":"Monica Campbell","orcid":null,"position":16,"is_corresponding":false},{"id":11238,"name":"Nicholas Rafaels","orcid":"0000-0002-2024-629X","position":17,"is_corresponding":false},{"id":18470,"name":"Kathleen C. Barnes","orcid":"0000-0002-3030-4705","position":18,"is_corresponding":false},{"id":87952,"name":"Anke H. Maitland‐van der Zee","orcid":"0000-0002-0414-3442","position":19,"is_corresponding":false},{"id":131000,"name":"Camila Alexandrina Figueiredo","orcid":"0000-0003-1356-6188","position":20,"is_corresponding":false},{"id":1471453,"name":"Ryan dos Santos Costa","orcid":"0000-0003-3075-0729","position":21,"is_corresponding":false},{"id":1471452,"name":"Maria Borges Rabêlo de Santana","orcid":"0000-0001-9455-8440","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:56:44.340853Z","pmid":"40677615","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}