{"doi":"10.1016/j.jacig.2024.100347","title":"Effect of prednisone on woodsmoke-induced sputum inflammation in healthy volunteers: A randomized, placebo-controlled pilot study","abstract":"Background Inhalation of biomass smoke is associated with adverse respiratory effects in those with chronic pulmonary conditions. There are few published data regarding the effects of anti-inflammatory interventions on these outcomes. Objective Our aim was to assess the effects of postexposure prednisone on woodsmoke (WS)-induced sputum neutrophilia. Methods We carried out a randomized, placebo-controlled, crossover pilot study assessing the effect of a postexposure dose of 60 mg prednisone on induced sputum inflammation after controlled exposure to WS (500 μg/m 3 for 2 hours) in healthy adults who had been identified in a separate screening protocol as being \"PMN responsive\" to WS. Secondary end points were sputum cytokine level and mucociliary clearance as measured by γ-scintigraphy. Results A total of 11 subjects yielded complete data for the primary analysis. At 24 hours after WS exposure, there was a significant increase in sputum percentage of PMNs (%PMN) versus at baseline after placebo (median = 42% [IQR = 31%-53%]) ( P = .02) but not after prednisone (median = 32% [IQR = 18%-40%]) ( P = .09). Prednisone reduced Δ%PMN at 24 hours, but this difference did not reach statistical significance. However, for the 8 of 11 subjects who were PMN responsive after placebo, prednisone reduced Δ%PMN significantly ( P = .05). Prednisone had no significant effects on sputum levels of IL-1β, IL-6, IL-8, or TNF-α. WS exposure tended to reduce mucociliary clearance in the placebo arm but not in the prednisone arm. Conclusions Prednisone taken immediately after exposure to WS mitigated short-term increase in sputum %PMN among healthy volunteers selected for their underlying inflammatory responsiveness to WS. Our data support future studies assessing anti-inflammatory interventions and the role of mucus clearance in WS-induced respiratory health effects.","journal":"Journal of Allergy and Clinical Immunology Global","year":2024,"id":458561,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":350030,"name":"Neil E. Alexis","orcid":"0000-0002-9417-8269","position":1,"is_corresponding":false},{"id":284286,"name":"William D. Bennett","orcid":"0000-0002-6054-0768","position":2,"is_corresponding":false},{"id":442309,"name":"Michelle L. Hernandez","orcid":"0000-0002-0925-1872","position":3,"is_corresponding":false},{"id":655471,"name":"Allison J. Burbank","orcid":"0000-0002-5469-0225","position":4,"is_corresponding":false},{"id":131633,"name":"Haolin Li","orcid":"0000-0003-3456-1845","position":5,"is_corresponding":false},{"id":533478,"name":"Haibo Zhou","orcid":"0009-0006-2166-5046","position":6,"is_corresponding":false},{"id":105528,"name":"Ilona Jaspers","orcid":"0000-0001-8728-0305","position":7,"is_corresponding":false},{"id":492241,"name":"David B. Peden","orcid":"0000-0003-4526-4627","position":8,"is_corresponding":false},{"id":442432,"name":"Terry L. Noah","orcid":"0000-0002-5134-3164","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:03:50.608887Z","pmid":"39524042","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}