{"doi":"10.1016/j.jacig.2023.100177","title":"A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke–induced neutrophilic and eosinophilic airway inflammation","abstract":"BackgroundAir pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced inflammation.ObjectiveThe objective of this study was to determine whether γ-tocopherol would prevent experimental wood smoke–induced airway inflammation in humans.MethodsThis was a randomized, placebo-controlled clinical trial testing the effect of a short course of γ-tocopherol–enriched supplementation on airway inflammation following a controlled exposure to wood smoke particulates.ResultsShort-course γ-tocopherol intervention did not reduce wood smoke–induced neutrophilic airway inflammation, but it did prevent wood smoke–induced eosinophilic airway inflammation.Conclusionγ-Tocopherol is a potential intervention for exacerbation of allergic airway inflammation, but further study examining longer dosing periods is required. Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced inflammation. The objective of this study was to determine whether γ-tocopherol would prevent experimental wood smoke–induced airway inflammation in humans. This was a randomized, placebo-controlled clinical trial testing the effect of a short course of γ-tocopherol–enriched supplementation on airway inflammation following a controlled exposure to wood smoke particulates. Short-course γ-tocopherol intervention did not reduce wood smoke–induced neutrophilic airway inflammation, but it did prevent wood smoke–induced eosinophilic airway inflammation. γ-Tocopherol is a potential intervention for exacerbation of allergic airway inflammation, but further study examining longer dosing periods is required.","journal":"Journal of Allergy and Clinical Immunology Global","year":2023,"id":377720,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":493130,"name":"Martha Almond","orcid":null,"position":1,"is_corresponding":false},{"id":1141364,"name":"Christian Brooks","orcid":"0000-0002-6782-0711","position":2,"is_corresponding":false},{"id":493131,"name":"Carole Robinette","orcid":null,"position":3,"is_corresponding":false},{"id":624136,"name":"Heather Wells","orcid":"0000-0002-1724-5843","position":4,"is_corresponding":false},{"id":655471,"name":"Allison J. Burbank","orcid":"0000-0002-5469-0225","position":5,"is_corresponding":false},{"id":442309,"name":"Michelle L. Hernandez","orcid":"0000-0002-0925-1872","position":6,"is_corresponding":false},{"id":385936,"name":"Alan L. Hinderliter","orcid":"0000-0002-3262-5668","position":7,"is_corresponding":false},{"id":323654,"name":"Melissa C. Caughey","orcid":"0000-0001-8433-5147","position":8,"is_corresponding":false},{"id":1141365,"name":"Qing Jiang","orcid":"0000-0002-1487-0651","position":9,"is_corresponding":false},{"id":1059860,"name":"Qianyue Wang","orcid":null,"position":10,"is_corresponding":false},{"id":131633,"name":"Haolin Li","orcid":"0000-0003-3456-1845","position":11,"is_corresponding":false},{"id":533478,"name":"Haibo Zhou","orcid":"0009-0006-2166-5046","position":12,"is_corresponding":false},{"id":350030,"name":"Neil E. Alexis","orcid":"0000-0002-9417-8269","position":13,"is_corresponding":false},{"id":492241,"name":"David B. Peden","orcid":"0000-0003-4526-4627","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37876758","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}