{"doi":"10.1016/j.jacig.2023.100093","title":"Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure","abstract":"Background: Given the increasing prevalence of wildfires worldwide, understanding the effects of wildfire air pollutants on human health-particularly in specific immunologic pathways-is crucial. Exposure to air pollutants is associated with cardiorespiratory disease; however, immune and epithelial barrier alterations require further investigation. Objective: We sought to determine the impact of wildfire smoke exposure on the immune system and epithelial barriers by using proteomics and immune cell phenotyping. Methods: A San Francisco Bay area cohort (n = 15; age 30 ± 10 years) provided blood samples before (October 2019 to March 2020; air quality index = 37) and during (August 2020; air quality index = 80) a major wildfire. Exposure samples were collected 11 days (range, 10-12 days) after continuous exposure to wildfire smoke. We determined alterations in 506 proteins, including zonulin family peptide (ZFP); immune cell phenotypes by cytometry by time of flight (CyTOF); and their interrelationship using a correlation matrix. Results: 2 cells). Conclusion: We observed functional changes in critical immune cells and their proteins during wildfire smoke exposure. Future studies in larger cohorts or in firefighters exposed to wildfire smoke should further assess immune changes and intervention targets.","journal":"Journal of Allergy and Clinical Immunology Global","year":2023,"id":359174,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9696,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":559517,"name":"Abhinav Kaushik","orcid":"0000-0001-5682-0209","position":1,"is_corresponding":false},{"id":352638,"name":"Nicholas Cauwenberghs","orcid":"0000-0001-8059-7692","position":2,"is_corresponding":false},{"id":630130,"name":"Anja Heider","orcid":"0000-0002-3448-4125","position":3,"is_corresponding":false},{"id":666200,"name":"İsmail Öğülür","orcid":"0000-0001-8282-7762","position":4,"is_corresponding":false},{"id":855844,"name":"Duygu Yazıcı","orcid":"0000-0001-9094-6542","position":5,"is_corresponding":false},{"id":630131,"name":"Eric Smith","orcid":"0000-0002-1262-3112","position":6,"is_corresponding":false},{"id":237675,"name":"Shifaa Alkotob","orcid":"0000-0003-4244-9482","position":7,"is_corresponding":false},{"id":352637,"name":"Mary Prunicki","orcid":"0000-0002-5511-8896","position":8,"is_corresponding":false},{"id":281744,"name":"Cezmi A. Akdiş","orcid":"0000-0001-8020-019X","position":9,"is_corresponding":false},{"id":36438,"name":"Kari C. Nadeau","orcid":"0000-0002-2146-2955","position":10,"is_corresponding":false},{"id":885840,"name":"Juan Aguilera","orcid":"0000-0002-6451-0662","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:13:52.889556Z","pmid":"37539354","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}