{"doi":"10.1016/j.jacig.2023.100092","title":"Model-estimated impacts of pediatric respiratory syncytial virus prevention programs in Mali on asthma prevalence","abstract":"Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection (LRTI) in young children and is associated with subsequent recurrent wheezing illness and asthma (wheeze/asthma). RSV prevention may therefore reduce wheeze/asthma prevalence. Objectives: We estimated the contribution of RSV LRTI and the impact of RSV prevention on recurrent wheeze/asthma in Mali. Methods: We simulated 12 consecutive monthly birth cohorts in Mali and estimated RSV LRTI cases through 2 years and recurrent wheeze/asthma prevalence at 6 years under different RSV prevention scenarios: status quo, seasonal birth-dose extended half-life mAb, and seasonal birth-dose extended half-life mAb followed by 2 doses of pediatric vaccine (mAb + vaccine). We used World Health Organization (WHO) Preferred Product Characteristics for RSV prevention, demographic and RSV epidemiologic data from Mali, regional recurrent wheeze/asthma prevalence, and relative risk of recurrent wheeze/asthma given early childhood RSV LRTI. Results: Among the simulated cohort of 778,680 live births, 10.0% had RSV LRTI by 2 years and 89.6% survived to 6 years. We estimated that 13.4% of all recurrent wheeze/asthma at 6 years was attributable to RSV LRTI. Recurrent wheeze/asthma prevalence at 6 years was 145.0 per 10,000 persons (RSV LRTI attributable) and 1084.2 per 10,000 persons (total). In mAb and mAb + vaccine scenarios, RSV LRTI cases decreased by 11.8% and 44.4%, respectively, and recurrent wheeze/asthma prevalence decreased by 11.8% and 44.4% (RSV LRTI attributable) and 1.6% and 5.9% (total). Conclusion: In Mali, RSV prevention programs may have a meaningful impact on chronic respiratory disease, strengthening the case for investment in RSV prevention.","journal":"Journal of Allergy and Clinical Immunology Global","year":2023,"id":387991,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8821,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":696496,"name":"Rachel S. Laufer","orcid":"0000-0003-3142-9347","position":1,"is_corresponding":false},{"id":275867,"name":"Steven M. Brunwasser","orcid":"0000-0002-3476-5437","position":2,"is_corresponding":false},{"id":697272,"name":"Flanon Coulibaly","orcid":null,"position":3,"is_corresponding":false},{"id":696498,"name":"Fatoumata Diallo","orcid":"0000-0002-1423-3417","position":4,"is_corresponding":false},{"id":697273,"name":"Moussa Doumbia","orcid":null,"position":5,"is_corresponding":false},{"id":227086,"name":"Amanda J. Driscoll","orcid":"0000-0003-1385-960X","position":6,"is_corresponding":false},{"id":275869,"name":"Deshayne B. Fell","orcid":"0000-0002-5548-3228","position":7,"is_corresponding":false},{"id":299786,"name":"Fadima Cheick Haidara","orcid":"0000-0003-1121-2941","position":8,"is_corresponding":false},{"id":275878,"name":"Tina V. Hartert","orcid":"0000-0001-7470-1166","position":9,"is_corresponding":false},{"id":585554,"name":"Adama Mamby Keita","orcid":"0000-0002-0315-0632","position":10,"is_corresponding":false},{"id":38212,"name":"Kathleen M. Neuzil","orcid":"0000-0001-9480-2714","position":11,"is_corresponding":false},{"id":275868,"name":"Brittney M. Snyder","orcid":"0000-0001-8356-3965","position":12,"is_corresponding":false},{"id":299788,"name":"Samba O. Sow","orcid":"0000-0002-6335-5066","position":13,"is_corresponding":false},{"id":225894,"name":"Meagan C. Fitzpatrick","orcid":"0000-0002-5248-2668","position":14,"is_corresponding":false},{"id":61306,"name":"Justin R. Ortiz","orcid":"0000-0002-3138-5965","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T01:18:13.977537Z","pmid":"37215432","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}