{"doi":"10.1016/j.jaci.2026.03.021","title":"Heterogeneity and clinical relevance of group 2 innate lymphoid cells subsets in nasal polyps","abstract":null,"journal":"Journal of Allergy and Clinical Immunology","year":2026,"id":637024,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1213184,"name":"Naruhito Iwasaki","orcid":"0000-0001-5086-223X","position":1,"is_corresponding":false},{"id":656018,"name":"Julie A. Poposki","orcid":null,"position":2,"is_corresponding":false},{"id":1195512,"name":"Noriko Ogasawara","orcid":"0000-0002-6014-3607","position":3,"is_corresponding":false},{"id":1213185,"name":"Aiko Oka","orcid":"0000-0002-3648-2879","position":4,"is_corresponding":false},{"id":656019,"name":"Aiko I. Klingler","orcid":null,"position":5,"is_corresponding":false},{"id":656020,"name":"Lydia Suh","orcid":null,"position":6,"is_corresponding":false},{"id":1653777,"name":"Aditi Agrwal","orcid":null,"position":7,"is_corresponding":false},{"id":848058,"name":"Junqin Bai","orcid":"0000-0001-6012-2809","position":8,"is_corresponding":false},{"id":233265,"name":"Whitney W. Stevens","orcid":"0000-0002-2608-6610","position":9,"is_corresponding":false},{"id":233266,"name":"Anju T. Peters","orcid":"0000-0003-0745-2379","position":10,"is_corresponding":false},{"id":233260,"name":"Leslie C. Grammer","orcid":"0000-0001-6860-2014","position":11,"is_corresponding":false},{"id":480725,"name":"Kevin C. Welch","orcid":"0000-0003-4863-7206","position":12,"is_corresponding":false},{"id":520504,"name":"Stephanie S. Smith","orcid":"0000-0002-0605-3993","position":13,"is_corresponding":false},{"id":392933,"name":"Micah Johnson","orcid":"0000-0001-6625-2719","position":14,"is_corresponding":false},{"id":841931,"name":"Amr Radwan","orcid":"0000-0003-1658-5229","position":15,"is_corresponding":false},{"id":480724,"name":"David B. Conley","orcid":"0000-0002-2611-6795","position":16,"is_corresponding":false},{"id":233264,"name":"Robert P. Schleimer","orcid":"0000-0002-8330-0097","position":17,"is_corresponding":false},{"id":386199,"name":"Robert C. Kern","orcid":"0000-0002-8995-9175","position":18,"is_corresponding":false},{"id":348700,"name":"Bruce K. Tan","orcid":"0000-0001-9210-5050","position":19,"is_corresponding":false},{"id":1387046,"name":"Mitsuhiro Okano","orcid":"0000-0002-4275-5781","position":20,"is_corresponding":false},{"id":921803,"name":"Shigeharu Fujieda","orcid":"0000-0002-9460-7377","position":21,"is_corresponding":false},{"id":262060,"name":"Atsushi Kato","orcid":"0000-0001-9144-3138","position":22,"is_corresponding":false},{"id":1213186,"name":"Masanori Kidoguchi","orcid":"0000-0002-2599-4780","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Heterogeneity and clinical relevance of group 2 innate lymphoid cells subsets in nasal polyps","abstract":"BACKGROUND: Chronic rhinosinusitis with nasal polyps is characterized by type 2 (T2) inflammation with elevated IL-5 and IL-13. Although group 2 innate lymphoid cells (ILC2s) drive T2 inflammation, their subset diversity and clinical relevance in nasal polyps (NPs) remain unclear. OBJECTIVE: We investigated cellular sources of T2 cytokines, subset heterogeneity of ILC2s, and the relationship between ILC2 subsets and clinical severity in chronic rhinosinusitis with NPs. METHODS: T cells were isolated from NP tissue and analyzed for cytokine production. ILC2s from 6 NP and 4 peripheral blood samples underwent single-cell RNA sequencing. Differential gene expression, subset heterogeneity, and pseudotime trajectory analyses were performed. Flow cytometry validated ILC2 subsets and associations with clinical parameters. RESULTS: 2 cells. NP-derived ILC2s showed downregulation of early developmental and trafficking genes (CD48, S1PR1) and upregulation of T2-associated cytokines (IL5, IL13), chemokines (XCL1, CXCL8), remodeling factors (AREG, TNFSF14), and METRNL. Four ILC2 subsets reflecting activation states were identified: migratory (tissue-homing with less activation), transitional (intermediate activation), inflammatory (high activation and T2 cytokines), and exhausted-like (expression of inhibitory receptors [eg, TIGIT]). The combined number of T2 cytokine-enriched subsets (transitional, inflammatory, and exhausted-like ILC2s) correlated with Lund-Mackay computed tomography scores. Inflammatory and exhausted-like ILC2s were associated with clinical symptom severity. CONCLUSION: ILC2s are one of the important effector populations driving local T2 inflammation in NPs and include 4 subsets with specific clinical associations. Subset-level ILC2 profiling may clarify chronic rhinosinusitis with NP pathophysiology and inform clinical stratification.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41956382","pmcid":"PMC13195586","openalex_id":"https://openalex.org/W7151417606","authors":[],"funders":[{"funder_name":"National Cancer Institute","grant_id":"CCSG P30 CA060553","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI104733","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P01 AI145818","title":null},{"funder_name":"AMED","grant_id":"","title":null},{"funder_name":"University of California, Los Angeles","grant_id":"","title":null},{"funder_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","grant_id":"","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"","title":null},{"funder_name":"Northwestern University","grant_id":"","title":null},{"funder_name":"Regeneron Pharmaceuticals Inc","grant_id":"","title":null},{"funder_name":"NIH NIAID","grant_id":"","title":null},{"funder_name":"Sanofi US","grant_id":"","title":null},{"funder_name":"Uehara Memorial Foundation","grant_id":"","title":null}],"total_grants":12,"fwci":8.0463,"citation_percentile":0.97515503,"influential_citations":0,"citation_trend":[{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jaci.2026.03.021","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jaci.2026.03.021","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0091674926002526?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0091674926002526?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41956382","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13195586/","host_type":"repository"}],"fields_of_study":["IL-33, ST2, and ILC Pathways","Sinusitis and nasal conditions","Pediatric health and respiratory diseases","Humans","Nasal Polyps","Immunity, Innate","Rhinosinusitis","Female","Male","Lymphocytes","Adult","Chronic Disease","Middle Aged","Cytokines","Lymphocyte Subsets","Sinusitis","Th2 Cells"],"mesh_terms":["Rhinosinusitis","Adult","Chronic Disease","Female","Humans","Immunity, Innate","Lymphocytes","Male","Middle Aged","Nasal Polyps","Sinusitis","Lymphocyte Subsets","Cytokines","Th2 Cells"],"keywords":["Innate lymphoid cell","Nasal polyps","Clinical significance","Chemokine","Sinusitis","Inflammation","Downregulation and upregulation","Cytokine","Rhinosinusitis","Rna Sequencing","Group 2 Innate Lymphoid Cells","Type 2 Immune Response"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:09:46.803906Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}