{"doi":"10.1016/j.jaci.2023.09.011","title":"Climate change and epigenetic biomarkers in allergic and airway diseases","abstract":"Human epigenetic variation is associated with both environmental exposures and allergic diseases and can potentially serve as a biomarker connecting climate change with allergy and airway diseases. In this narrative review, we summarize recent human epigenetic studies examining exposure to temperature, precipitation, extreme weather events, and malnutrition to discuss findings as they relate to allergic and airway diseases. Temperature has been the most widely studied exposure, with the studies implicating both short-term and long-term exposures with epigenetic alterations and epigenetic aging. Few studies have examined natural disasters or extreme weather events. The studies available have reported differential DNA methylation of multiple genes and pathways, some of which were previously associated with asthma or allergy. Few studies have integrated climate-related events, epigenetic biomarkers, and allergic disease together. Prospective longitudinal studies are needed along with the collection of target tissues beyond blood samples, such as nasal and skin cells. Finally, global collaboration to increase diverse representation of study participants, particularly those most affected by climate injustice, as well as strengthen replication, validation, and harmonization of measurements will be needed to elucidate the impacts of climate change on the human epigenome. Human epigenetic variation is associated with both environmental exposures and allergic diseases and can potentially serve as a biomarker connecting climate change with allergy and airway diseases. In this narrative review, we summarize recent human epigenetic studies examining exposure to temperature, precipitation, extreme weather events, and malnutrition to discuss findings as they relate to allergic and airway diseases. Temperature has been the most widely studied exposure, with the studies implicating both short-term and long-term exposures with epigenetic alterations and epigenetic aging. Few studies have examined natural disasters or extreme weather events. The studies available have reported differential DNA methylation of multiple genes and pathways, some of which were previously associated with asthma or allergy. Few studies have integrated climate-related events, epigenetic biomarkers, and allergic disease together. Prospective longitudinal studies are needed along with the collection of target tissues beyond blood samples, such as nasal and skin cells. Finally, global collaboration to increase diverse representation of study participants, particularly those most affected by climate injustice, as well as strengthen replication, validation, and harmonization of measurements will be needed to elucidate the impacts of climate change on the human epigenome. The climate crisis is one of the greatest threats to humanity, with significant impacts on allergic, immunologic, and respiratory health.1Watts N. Amann M. Arnell N. Ayeb-Karlsson S. Belesova K. Boykoff M. et al.The 2019 report of the Lancet Countdown on Health and Climate Change: ensuring that the health of a child born today is not defined by a changing climate.Lancet. 2019; 394: 1836-1878Abstract Full Text Full Text PDF PubMed Scopus (825) Google Scholar, 2D’Amato G. Holgate S.T. Pawankar R. Ledford D.K. Cecchi L. Al-Ahmad M. et al.Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.World Allergy Organ J. 2015; 8: 25Abstract Full Text Full Text PDF PubMed Scopus (352) Google Scholar, 3Katelaris C.H. Beggs P.J. Climate change: allergens and allergic diseases.Intern Med J. 2018; 48: 129-134Crossref PubMed Scopus (73) Google Scholar, 4D’Amato G. Chong-Neto H.J. Monge Ortega O.P. Vitale C. Ansotegui I. Rosario N. et al.The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens.Allergy. 2020; 75: 2219-2228Crossref PubMed Scopus (160) Google Scholar, 5Sampath V. Aguile","journal":"Journal of Allergy and Clinical Immunology","year":2023,"id":326293,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":678041,"name":"Raj P. Fadadu","orcid":"0000-0002-7163-9237","position":1,"is_corresponding":false},{"id":107845,"name":"Supinda Bunyavanich","orcid":"0000-0001-6108-439X","position":2,"is_corresponding":false},{"id":274134,"name":"Andrés Cárdenas","orcid":"0000-0003-2284-3298","position":0,"is_corresponding":true}],"reference_count":108,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"37741554","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}