{"doi":"10.1016/j.jaci.2022.04.035","title":"Reproducibility of food challenge to cow’s milk: Systematic review with individual participant data meta-analysis","abstract":"BACKGROUND: Cow's milk (CM) is an increasingly common cause of severe allergic reactions, but there is uncertainty with respect to severity of reactions at low-level CM exposure, as well as the reproducibility of reaction thresholds. OBJECTIVE: We undertook an individual participant data (IPD) meta-analysis of studies reporting double-blind, placebo-controlled food challenges in CM to determine the rate of anaphylaxis to low-level exposures and the reproducibility of reaction thresholds. METHODS: We performed a systematic review and IPD meta-analysis of studies reporting relevant data. Authors were contacted to provide additional data and/or clarification as needed. Risk of bias was assessed using the National Institute for Clinical Excellence methodologic checklists. RESULTS: = 0%). Then 110 individuals underwent repeat double-blind, placebo-controlled food challenges; the intraindividual variation in reaction threshold was limited to a ½-log change in 80% (95% CI, 65-89) of participants. Two individuals initially tolerated 5 mg CM protein but then reacted to this dose at a subsequent challenge, although neither had anaphylaxis. CONCLUSIONS: dose, respectively, in the broader CM-allergic population. Most of these anaphylactic reactions would be mild and respond to a single dose of epinephrine.","journal":"Journal of Allergy and Clinical Immunology","year":2022,"id":253483,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9569,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":652081,"name":"Nandinee Patel","orcid":"0000-0002-4997-9411","position":1,"is_corresponding":false},{"id":623156,"name":"Dianne E. Campbell","orcid":"0000-0002-0907-6963","position":2,"is_corresponding":false},{"id":273996,"name":"Hugh A. Sampson","orcid":"0000-0003-1613-8875","position":3,"is_corresponding":false},{"id":899418,"name":"Mayu Maeda","orcid":"0000-0002-1573-7991","position":4,"is_corresponding":false},{"id":899419,"name":"Toshio Katsunuma","orcid":"0000-0003-2646-3006","position":5,"is_corresponding":false},{"id":247296,"name":"Joost Westerhout","orcid":"0000-0001-9068-0916","position":6,"is_corresponding":false},{"id":247298,"name":"W. Marty Blom","orcid":"0000-0002-6853-0900","position":7,"is_corresponding":false},{"id":247302,"name":"Joseph L. Baumert","orcid":"0000-0002-4502-5223","position":8,"is_corresponding":false},{"id":247301,"name":"Geert F. Houben","orcid":"0000-0001-7261-3912","position":9,"is_corresponding":false},{"id":247295,"name":"Benjamin C. Remington","orcid":"0000-0001-5450-8334","position":10,"is_corresponding":false},{"id":504690,"name":"Paul Turner","orcid":"0000-0001-9862-5161","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T00:24:59.596040Z","pmid":"35688284","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}