{"doi":"10.1016/j.jacep.2024.07.014","title":"Modeling Idiopathic Ventricular Fibrillation Using iPSC Cardiomyocytes and Computational Approaches","abstract":"Idiopathic ventricular fibrillation (IVF) is an unrefined diagnosis representing a heterogeneous patient group without a structural or genetic definition. IVF treatment is not mechanistic-based due to the lack of experimental patient-models. We sought to create a methodology to assess cellular arrhythmia mechanisms for IVF as a proof-of-concept study. Using IVF patient-specific induced pluripotent stem cell-derived cardiomyocytes, we integrate electrophysiological optical mapping with computational modeling to characterize the cellular phenotype. This approach flips the traditional paradigm using a biophysically detailed computational model to solve the problem inversely. Insight into the cellular mechanisms of this patient's IVF phenotype could also serve as a therapeutic testbed.","journal":"JACC. Clinical electrophysiology","year":2024,"id":466393,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9404,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":924961,"name":"Mitchell Josvai","orcid":"0009-0008-0574-6991","position":1,"is_corresponding":false},{"id":1298161,"name":"Manasa H. Kalluri","orcid":"0009-0001-8207-7727","position":2,"is_corresponding":false},{"id":336063,"name":"Corey L. Anderson","orcid":"0000-0002-6898-8479","position":3,"is_corresponding":false},{"id":471954,"name":"Haibo Ni","orcid":"0000-0003-0083-4286","position":4,"is_corresponding":false},{"id":658077,"name":"Kate M. Orland","orcid":"0000-0003-4510-448X","position":5,"is_corresponding":false},{"id":367299,"name":"Di Lang","orcid":"0000-0003-3318-4208","position":6,"is_corresponding":false},{"id":367303,"name":"Alexey V. Glukhov","orcid":"0000-0003-2076-9688","position":7,"is_corresponding":false},{"id":1298162,"name":"Eleonora Grandi","orcid":"0000-0002-2742-8096","position":8,"is_corresponding":false},{"id":367302,"name":"Lee L. Eckhardt","orcid":"0000-0001-5792-064X","position":9,"is_corresponding":false},{"id":649553,"name":"Louise Reilly","orcid":"0000-0002-2224-1708","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T02:04:54.606394Z","pmid":"39297840","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}