{"doi":"10.1016/j.jaccao.2021.06.005","title":"Sustained Increases in IGFBP-7 May Be Related to Doxorubicin in Breast Cancer Patients","abstract":"Insulin-like growth factor-binding protein-7 (IGFBP-7) is involved in cell senescence, and higher IGFBP-7 levels are associated with impaired myocardial compliance and diastolic dysfunction in patients with heart failure (HF) (1).However, the role of IGFBP-7 in cardio-oncology remains uncertain.We examined associations between changes in IGFBP-7 levels and echocardiographic measures of diastolic function in breast cancer patients receiving doxorubicin with or without trastuzumab.The Penn Cardiotoxicity of Cancer Therapy Study (NCT01173341) is a prospective longitudinal cohort of breast cancer patients from the Rena Rowan Breast Center of the Abramson Cancer Center at the University of Pennsylvania (Philadelphia, Pennsylvania).Details of the study design, population, and procedures have been described elsewhere (2).The study was approved by the local institutional review board.All patients provided written informed consent.Plasma IGFBP-7 was measured with the use of a precommercial COBAS Elecsys assay (Roche Diagnostics).The IGFBP-7 assay has a coefficient of variation (CV) of intra-assay precision <3% and interassay precision <6%.Quantitative echocardiography was performed by a sonographer blinded to patient clinical characteristics at the Penn Center for Quantitative Echocardiography (Philadelphia, Pennsylvania) with the use of TomTec Imaging Systems.Associations between baseline clinical variables and IGFBP-7 levels were evaluated by means of linear regression.Estimates of the mean (95% confidence interval [CI]) change from baseline, determined by means of repeated-measures linear regression via generalized estimating equations (GEE), were plotted over time to characterize changes in IGFBP-7 levels following doxorubicin initiation.Associations between changes in IGFBP-7 levels and echocardiographic diastolic function measures were determined with the use of repeated-measures linear regression via GEE.IGFBP-7","journal":"JACC CardioOncology","year":2021,"id":209556,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":797679,"name":"Biniyam G. Demessei","orcid":null,"position":1,"is_corresponding":false},{"id":255206,"name":"Amanda M. Smith","orcid":"0000-0002-9881-236X","position":2,"is_corresponding":false},{"id":255208,"name":"Joseph R. Carver","orcid":"0000-0001-8804-0653","position":3,"is_corresponding":false},{"id":797224,"name":"Liyong Zhang","orcid":"0000-0001-5963-9755","position":4,"is_corresponding":false},{"id":245351,"name":"Peter Liu","orcid":"0000-0002-8703-6967","position":5,"is_corresponding":false},{"id":97061,"name":"James L. Januzzi","orcid":"0000-0002-8338-1798","position":6,"is_corresponding":false},{"id":282965,"name":"Bonnie Ky","orcid":"0000-0002-6628-9981","position":7,"is_corresponding":false},{"id":797223,"name":"Nicholas S. Wilcox","orcid":"0000-0002-3693-7650","position":0,"is_corresponding":true}],"reference_count":4,"raw_metadata":null,"created_at":"2026-07-18T23:52:05.171356Z","pmid":"34604806","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}