{"doi":"10.1016/j.jaccao.2020.12.005","title":"The Incidence, Risk Factors, and Outcomes With 5-Fluorouracil–Associated Coronary Vasospasm","abstract":"BACKGROUND: Coronary vasospasm is a recognized side effect of 5-FU (fluorouracil). There are limited and conflicting data on the incidence, risk factors and prognostic effect of 5-FU associated vasospasm. OBJECTIVES: To assess the incidence, risk factors and prognostic implications of 5-FU coronary vasospasm among patients receiving 5-FU regimens at a single tertiary care center. METHODS: We conducted a retrospective analysis of all patients who received 5-FU at a single academic center from January 2009 to July 2019. Vasospasm was defined as the occurrence of a typical chest pain syndrome in the presence of 5-FU. The presence of associated electrocardiogram (ECG) changes and/or elevated biomarkers was used to further confirm the diagnosis. Patients with vasospasm were compared to patients treated with 5-FU without vasospasm in a 1:2 ratio. Data regarding demographics, medical history, and follow-up were collected by manual chart review. RESULTS: From approximately 4019 individual patients who received 5-FU from 2009 to 2019 at a single center, 87 (2.16%) developed vasospasm. Patients who developed vasospasm were younger (58±13 vs. 64±13 years, P = 0.001), and were less likely to have any cardiovascular risk factors (70.1% vs. 84.5%, P = 0.007). Patients with vasospasm and patients without vasospasm were otherwise similar in terms of types of cancer, stage of cancer, sex, and race. There was no significant difference in progression-free survival, overall mortality or cancer specific mortality between patients who developed vasospasm versus those who did not. CONCLUSION: In a large, single-center report of 5-FU associated vasospasm, patients who developed vasospasm were younger, had lower rates of traditional cardiovascular risk factors and had no significant difference in progression-free or overall survival compared to those who did not develop vasospasm.","journal":"JACC CardioOncology","year":2021,"id":152724,"datarank":0.6476232170304466,"base_score":4.31748811353631,"endowment":4.31748811353631,"self_citation_contribution":0.6476232170304466,"citation_network_contribution":0.0,"self_endowment_contribution":0.6476232170304466,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":74,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8843,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":308168,"name":"Zsófia D. Drobni","orcid":"0000-0002-1355-5318","position":1,"is_corresponding":false},{"id":648187,"name":"Ramya Mosarla","orcid":"0000-0002-8486-6279","position":2,"is_corresponding":false},{"id":234379,"name":"Raza M. Alvi","orcid":null,"position":3,"is_corresponding":false},{"id":648188,"name":"Matthew Lei","orcid":"0000-0001-5348-6065","position":4,"is_corresponding":false},{"id":648189,"name":"Uvette Lou","orcid":"0000-0001-9220-3646","position":5,"is_corresponding":false},{"id":402710,"name":"Vineet K. Raghu","orcid":"0000-0003-3524-3945","position":6,"is_corresponding":false},{"id":232172,"name":"Sean Murphy","orcid":"0000-0002-5928-5974","position":7,"is_corresponding":false},{"id":232175,"name":"Maeve Jones‐O’Connor","orcid":"0000-0002-0508-2493","position":8,"is_corresponding":false},{"id":309885,"name":"Sarah Hartmann","orcid":null,"position":9,"is_corresponding":false},{"id":309886,"name":"Hannah Gilman","orcid":null,"position":10,"is_corresponding":false},{"id":43404,"name":"Colin D. Weekes","orcid":"0000-0001-6287-4334","position":11,"is_corresponding":false},{"id":635466,"name":"John R. Clark","orcid":null,"position":12,"is_corresponding":false},{"id":230274,"name":"Jeffrey W. Clark","orcid":"0000-0001-9524-3600","position":13,"is_corresponding":false},{"id":260766,"name":"Lawrence S. Blaszkowsky","orcid":"0000-0002-9437-2977","position":14,"is_corresponding":false},{"id":648190,"name":"Erica Tavares","orcid":"0009-0003-8780-4393","position":15,"is_corresponding":false},{"id":232198,"name":"Tomas G. Neilan","orcid":"0000-0002-1513-8833","position":16,"is_corresponding":false},{"id":308169,"name":"Amna Zafar","orcid":"0000-0003-2010-3018","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:43:34.972031Z","pmid":"33817666","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}