{"doi":"10.1016/j.jaccao.2020.10.007","title":"Amyloidosis and 30-Day Outcomes Among Patients With Heart Failure","abstract":"BACKGROUND: The burden of amyloidosis among hospitalized patients is increasing over time. However, amyloidosis remains an underdiagnosed cause of heart failure (HF) hospitalization among older adults. OBJECTIVES: We investigated the prevalence and prognostic implications of amyloidosis among patients hospitalized with HF. METHODS: All hospitalizations for primary diagnosis of HF between January 1, 2010, and August 31, 2015, identified in the Nationwide Readmissions Database were categorized into those with and without a secondary diagnosis of amyloidosis. HF hospitalizations with amyloidosis were then matched in a 3:1 fashion to HF hospitalizations without amyloidosis using the year of admission, discharge quarter, age, sex, and Charlson comorbidity index. Primary outcomes were inpatient mortality and 30-day readmission. Multivariable logistic regression was used to estimate the association between HF with amyloidosis and clinical outcomes. RESULTS: Of 1,593,360 HF hospitalizations that met inclusion criteria, 2,846 (0.18%) had HF with a secondary diagnosis of amyloidosis and were matched to 8,515 hospitalizations for HF without amyloidosis. Hospitalizations for HF with amyloidosis were associated with higher prevalence of kidney disease (56% vs. 45%), malignancy (20% vs. 4%), and higher inpatient mortality (6% vs. 3%) as compared with HF without amyloidosis. In adjusted analyses, HF with amyloidosis was associated with higher odds of in-hospital mortality (odds ratio: 1.46; 95% confidence interval [CI]: 1.17 to 1.82), 30-day readmission (odds ratio: 1.17; 95% CI: 1.05 to 1.31), and longer mean length of stay (least-squares mean difference: 1.46; 95% CI: 1.12 to 1.80). CONCLUSIONS: In patients hospitalized with decompensated HF, presence of amyloidosis was associated with higher risk of inpatient mortality and 30-day readmission.","journal":"JACC CardioOncology","year":2020,"id":76588,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.906,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":399512,"name":"Nikita Patil","orcid":"0000-0002-6330-5042","position":1,"is_corresponding":false},{"id":399513,"name":"Paula D. Strassle","orcid":"0000-0002-1072-1560","position":2,"is_corresponding":false},{"id":260667,"name":"Arman Qamar","orcid":"0000-0003-0607-1240","position":3,"is_corresponding":false},{"id":61406,"name":"Muthiah Vaduganathan","orcid":"0000-0003-0885-1953","position":4,"is_corresponding":false},{"id":260666,"name":"Amber Fatima","orcid":"0000-0002-2380-9756","position":5,"is_corresponding":false},{"id":400873,"name":"Kalyan Mogili","orcid":null,"position":6,"is_corresponding":false},{"id":400874,"name":"Deepak Garipalli","orcid":null,"position":7,"is_corresponding":false},{"id":294598,"name":"Justin L. Grodin","orcid":"0000-0003-2400-3196","position":8,"is_corresponding":false},{"id":323655,"name":"John P. Vavalle","orcid":"0000-0002-7820-4789","position":9,"is_corresponding":false},{"id":97058,"name":"Gregg C. Fonarow","orcid":"0000-0002-3192-8093","position":10,"is_corresponding":false},{"id":3774,"name":"Deepak L. Bhatt","orcid":"0000-0002-1278-6245","position":11,"is_corresponding":false},{"id":294601,"name":"Ambarish Pandey","orcid":"0000-0001-9651-3836","position":12,"is_corresponding":false},{"id":323650,"name":"Sameer Arora","orcid":"0000-0002-6387-3015","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:48:27.511277Z","pmid":"34396285","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}